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3hsw

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[[Image:3hsw.png|left|200px]]
 
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{{STRUCTURE_3hsw| PDB=3hsw | SCENE= }}
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==Crystal Structure of Porcine Pancreatic Phospholipase A2 in Complex with 2-methoxycyclohexa-2-5-diene-1,4-dione==
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<StructureSection load='3hsw' size='340' side='right'caption='[[3hsw]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===Crystal Structure of Porcine Pancreatic Phospholipase A2 in Complex with 2-methoxycyclohexa-2-5-diene-1,4-dione===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3hsw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HSW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MCW:2-METHOXYCYCLOHEXA-2,5-DIENE-1,4-DIONE'>MCW</scene></td></tr>
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[[3hsw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSW OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hsw OCA], [https://pdbe.org/3hsw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hsw RCSB], [https://www.ebi.ac.uk/pdbsum/3hsw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hsw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PA21B_PIG PA21B_PIG] PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hs/3hsw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hsw ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Phospholipase A2|Phospholipase A2]]
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*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Dileep, K V.]]
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[[Category: Dileep KV]]
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[[Category: Haridas, M.]]
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[[Category: Haridas M]]
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[[Category: Karthe, P.]]
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[[Category: Karthe P]]
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[[Category: Mandal, P K.]]
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[[Category: Mandal PK]]
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[[Category: Sadasivan, C.]]
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[[Category: Sadasivan C]]
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[[Category: Tintu, I.]]
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[[Category: Tintu I]]
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[[Category: Curcumin binding]]
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[[Category: Disulfide bond]]
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[[Category: Hydrolase]]
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[[Category: Lipid degradation]]
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[[Category: Lipoprotein]]
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[[Category: Metal-binding]]
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[[Category: Palmitate]]
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[[Category: Pancreatic enzyme]]
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[[Category: Pla2]]
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[[Category: Pyrrolidone carboxylic acid]]
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[[Category: Secreted]]
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Current revision

Crystal Structure of Porcine Pancreatic Phospholipase A2 in Complex with 2-methoxycyclohexa-2-5-diene-1,4-dione

PDB ID 3hsw

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