1kog

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[[Image:1kog.png|left|200px]]
 
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{{STRUCTURE_1kog| PDB=1kog | SCENE= }}
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==Crystal structure of E. coli threonyl-tRNA synthetase interacting with the essential domain of its mRNA operator==
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<StructureSection load='1kog' size='340' side='right'caption='[[1kog]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1kog]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KOG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KOG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TSB:5-O-(N-(L-THREONYL)-SULFAMOYL)ADENOSINE'>TSB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kog OCA], [https://pdbe.org/1kog PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kog RCSB], [https://www.ebi.ac.uk/pdbsum/1kog PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kog ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SYT_ECOLI SYT_ECOLI] ThrS is also a translational repressor protein, it controls the translation of its own gene by binding to its mRNA.[HAMAP-Rule:MF_00184]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/1kog_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kog ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Escherichia coli threonyl-tRNA synthetase (ThrRS) represses the translation of its own messenger RNA by binding to an operator located upstream of the initiation codon. The crystal structure of the complex between the core of ThrRS and the essential domain of the operator shows that the mRNA uses the recognition mode of the tRNA anticodon loop to initiate binding. The final positioning of the operator, upon which the control mechanism is based, relies on a characteristic RNA motif adapted to the enzyme surface. The finding of other thrS operators that have this conserved motif leads to a generalization of this regulatory mechanism to a subset of Gram-negative bacteria.
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===Crystal structure of E. coli threonyl-tRNA synthetase interacting with the essential domain of its mRNA operator===
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Structural basis of translational control by Escherichia coli threonyl tRNA synthetase.,Torres-Larios A, Dock-Bregeon AC, Romby P, Rees B, Sankaranarayanan R, Caillet J, Springer M, Ehresmann C, Ehresmann B, Moras D Nat Struct Biol. 2002 May;9(5):343-7. PMID:11953757<ref>PMID:11953757</ref>
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{{ABSTRACT_PUBMED_11953757}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1kog" style="background-color:#fffaf0;"></div>
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[[1kog]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KOG OCA].
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==See Also==
==See Also==
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*[[Aminoacyl tRNA Synthetase|Aminoacyl tRNA Synthetase]]
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:011953757</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Threonine--tRNA ligase]]
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[[Category: Large Structures]]
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[[Category: Caillet, J.]]
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[[Category: Caillet J]]
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[[Category: Dock-Bregeon, A C.]]
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[[Category: Dock-Bregeon AC]]
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[[Category: Ehresmann, B.]]
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[[Category: Ehresmann B]]
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[[Category: Ehresmann, C.]]
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[[Category: Ehresmann C]]
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[[Category: Moras, D.]]
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[[Category: Moras D]]
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[[Category: Rees, B.]]
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[[Category: Rees B]]
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[[Category: Romby, P.]]
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[[Category: Romby P]]
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[[Category: Sankaranarayanan, R.]]
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[[Category: Sankaranarayanan R]]
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[[Category: Springer, M.]]
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[[Category: Springer M]]
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[[Category: Torres-Larrios, A.]]
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[[Category: Torres-Larrios A]]
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[[Category: Ligase-rna complex]]
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[[Category: Protein-rna complex]]
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[[Category: Rna base triple]]
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[[Category: Rna double helix]]
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[[Category: Rna stem-loop]]
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Current revision

Crystal structure of E. coli threonyl-tRNA synthetase interacting with the essential domain of its mRNA operator

PDB ID 1kog

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