1x7b

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:48, 14 February 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1x7b.png|left|200px]]
 
-
{{STRUCTURE_1x7b| PDB=1x7b | SCENE= }}
+
==CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH ERB-041==
-
 
+
<StructureSection load='1x7b' size='340' side='right'caption='[[1x7b]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
===CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH ERB-041===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1x7b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X7B FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_15548008}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=041:2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL'>041</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x7b OCA], [https://pdbe.org/1x7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x7b RCSB], [https://www.ebi.ac.uk/pdbsum/1x7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x7b ProSAT]</span></td></tr>
-
[[1x7b]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X7B OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x7/1x7b_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x7b ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Estrogen receptor|Estrogen receptor]]
+
*[[Estrogen receptor 3D structures|Estrogen receptor 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:015548008</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Akopian, T.]]
+
[[Category: Large Structures]]
-
[[Category: Alvarez, J C.]]
+
[[Category: Akopian T]]
-
[[Category: Bapat, A.]]
+
[[Category: Alvarez JC]]
-
[[Category: Bhat, R A.]]
+
[[Category: Bapat A]]
-
[[Category: Harris, H A.]]
+
[[Category: Bhat RA]]
-
[[Category: Hsiao, C.]]
+
[[Category: Harris HA]]
-
[[Category: Hum, W T.]]
+
[[Category: Hsiao C]]
-
[[Category: Malakian, K.]]
+
[[Category: Hum WT]]
-
[[Category: Malamas, M S.]]
+
[[Category: Malakian K]]
-
[[Category: Manas, E S.]]
+
[[Category: Malamas MS]]
-
[[Category: Miller, C P.]]
+
[[Category: Manas ES]]
-
[[Category: Somers, W S.]]
+
[[Category: Miller CP]]
-
[[Category: Stahl, M L.]]
+
[[Category: Somers WS]]
-
[[Category: Unwalla, R J.]]
+
[[Category: Stahl ML]]
-
[[Category: Wolfrom, S.]]
+
[[Category: Unwalla RJ]]
-
[[Category: Xu, Z B.]]
+
[[Category: Wolfrom S]]
-
[[Category: Agonist]]
+
[[Category: Xu ZB]]
-
[[Category: Er]]
+
-
[[Category: Er-beta]]
+
-
[[Category: Estrogen]]
+
-
[[Category: Estrogen receptor]]
+
-
[[Category: Estrogen receptor beta]]
+
-
[[Category: Nuclear receptor]]
+
-
[[Category: Transcription]]
+
-
[[Category: Transcription factor]]
+

Current revision

CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH ERB-041

PDB ID 1x7b

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1x7b"
Personal tools