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1xhx

From Proteopedia

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[[Image:1xhx.png|left|200px]]
 
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{{STRUCTURE_1xhx| PDB=1xhx | SCENE= }}
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==Phi29 DNA Polymerase, orthorhombic crystal form==
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<StructureSection load='1xhx' size='340' side='right'caption='[[1xhx]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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===Phi29 DNA Polymerase, orthorhombic crystal form===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1xhx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_virus_phi29 Bacillus virus phi29]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XHX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XHX FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15546620}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xhx OCA], [https://pdbe.org/1xhx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xhx RCSB], [https://www.ebi.ac.uk/pdbsum/1xhx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xhx ProSAT]</span></td></tr>
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[[1xhx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_phage_phi29 Bacillus phage phi29]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XHX OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DPOL_BPPH2 DPOL_BPPH2] This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xh/1xhx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xhx ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[DNA polymerase|DNA polymerase]]
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:015546620</ref><references group="xtra"/>
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[[Category: Bacillus virus phi29]]
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[[Category: Bacillus phage phi29]]
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[[Category: Large Structures]]
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Berman AJ]]
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[[Category: Berman, A J.]]
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[[Category: Blanco L]]
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[[Category: Blanco, L.]]
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[[Category: Kamtekar S]]
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[[Category: Kamtekar, S.]]
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[[Category: Lazaro JM]]
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[[Category: Lazaro, J M.]]
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[[Category: Salas M]]
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[[Category: Salas, M.]]
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[[Category: Steitz TA]]
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[[Category: Steitz, T A.]]
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[[Category: Wang J]]
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[[Category: Vega, M de.]]
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[[Category: De Vega M]]
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[[Category: Wang, J.]]
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[[Category: Dna polymerase]]
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[[Category: Processivity]]
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[[Category: Protein-primed]]
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[[Category: Replication]]
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[[Category: Strand displacement]]
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[[Category: Transferase]]
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Current revision

Phi29 DNA Polymerase, orthorhombic crystal form

PDB ID 1xhx

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