2ous

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[[Image:2ous.png|left|200px]]
 
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{{STRUCTURE_2ous| PDB=2ous | SCENE= }}
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==crystal structure of PDE10A2 mutant D674A==
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<StructureSection load='2ous' size='340' side='right'caption='[[2ous]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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===crystal structure of PDE10A2 mutant D674A===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ous]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OUS FirstGlance]. <br>
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{{ABSTRACT_PUBMED_17389385}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ous FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ous OCA], [https://pdbe.org/2ous PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ous RCSB], [https://www.ebi.ac.uk/pdbsum/2ous PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ous ProSAT]</span></td></tr>
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[[2ous]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OUS OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ou/2ous_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ous ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Phosphodiesterase|Phosphodiesterase]]
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:017389385</ref><references group="xtra"/>
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__TOC__
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[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hou, J.]]
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[[Category: Large Structures]]
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[[Category: Liu, Y D.]]
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[[Category: Hou J]]
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[[Category: Robinson, H.]]
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[[Category: Liu YD]]
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[[Category: Wang, H C.]]
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[[Category: Robinson H]]
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[[Category: Zheng, M Y.]]
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[[Category: Wang HC]]
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[[Category: Hydrolase]]
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[[Category: Zheng MY]]
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[[Category: Pde]]
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Current revision

crystal structure of PDE10A2 mutant D674A

PDB ID 2ous

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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