2b50

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[[Image:2b50.png|left|200px]]
 
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{{STRUCTURE_2b50| PDB=2b50 | SCENE= }}
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==Human Nuclear Receptor-Ligand Complex 2==
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<StructureSection load='2b50' size='340' side='right'caption='[[2b50]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===Human Nuclear Receptor-Ligand Complex 2===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2b50]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B50 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16405912}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B7G:HEPTYL-BETA-D-GLUCOPYRANOSIDE'>B7G</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=VCA:VACCENIC+ACID'>VCA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b50 OCA], [https://pdbe.org/2b50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b50 RCSB], [https://www.ebi.ac.uk/pdbsum/2b50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b50 ProSAT]</span></td></tr>
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[[2b50]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B50 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b5/2b50_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b50 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Peroxisome Proliferator-Activated Receptors|Peroxisome Proliferator-Activated Receptors]]
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*[[Peroxisome proliferator-activated receptor 3D structures|Peroxisome proliferator-activated receptor 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016405912</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Alphey, M S.]]
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[[Category: Large Structures]]
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[[Category: Bjorkling, F.]]
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[[Category: Alphey MS]]
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[[Category: Buetow, L.]]
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[[Category: Bjorkling F]]
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[[Category: Ferguson, M A.J.]]
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[[Category: Buetow L]]
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[[Category: Fyffe, S A.]]
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[[Category: Ferguson MAJ]]
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[[Category: Hunter, W N.]]
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[[Category: Fyffe SA]]
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[[Category: Smith, T K.]]
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[[Category: Hunter WN]]
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[[Category: Sorensen, M D.]]
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[[Category: Smith TK]]
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[[Category: Gene regulation]]
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[[Category: Sorensen MD]]
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[[Category: Nuclear receptor]]
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[[Category: Ppar]]
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[[Category: Protein-ligand complex]]
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Current revision

Human Nuclear Receptor-Ligand Complex 2

PDB ID 2b50

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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