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2b50
From Proteopedia
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| - | [[Image:2b50.png|left|200px]] | ||
| - | + | ==Human Nuclear Receptor-Ligand Complex 2== | |
| - | + | <StructureSection load='2b50' size='340' side='right'caption='[[2b50]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2b50]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B50 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B7G:HEPTYL-BETA-D-GLUCOPYRANOSIDE'>B7G</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=VCA:VACCENIC+ACID'>VCA</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b50 OCA], [https://pdbe.org/2b50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b50 RCSB], [https://www.ebi.ac.uk/pdbsum/2b50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b50 ProSAT]</span></td></tr> |
| - | [[2b50]] is a 2 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b5/2b50_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b50 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Peroxisome | + | *[[Peroxisome proliferator-activated receptor 3D structures|Peroxisome proliferator-activated receptor 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Alphey | + | [[Category: Large Structures]] |
| - | [[Category: Bjorkling | + | [[Category: Alphey MS]] |
| - | [[Category: Buetow | + | [[Category: Bjorkling F]] |
| - | [[Category: Ferguson | + | [[Category: Buetow L]] |
| - | [[Category: Fyffe | + | [[Category: Ferguson MAJ]] |
| - | [[Category: Hunter | + | [[Category: Fyffe SA]] |
| - | [[Category: Smith | + | [[Category: Hunter WN]] |
| - | [[Category: Sorensen | + | [[Category: Smith TK]] |
| - | + | [[Category: Sorensen MD]] | |
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Current revision
Human Nuclear Receptor-Ligand Complex 2
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Categories: Homo sapiens | Large Structures | Alphey MS | Bjorkling F | Buetow L | Ferguson MAJ | Fyffe SA | Hunter WN | Smith TK | Sorensen MD
