1nye

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[[Image:1nye.gif|left|200px]]<br /><applet load="1nye" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1nye, resolution 2.40&Aring;" />
 
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'''Crystal structure of OsmC from E. coli'''<br />
 
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==Overview==
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==Crystal structure of OsmC from E. coli==
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The crystal structure of an osmotically inducible protein (OsmC) from Escherichia coli has been determined at 2.4 A resolution. OsmC is a representative protein of the OsmC sequence family, which is composed of three sequence subfamilies. The structure of OsmC provides a view of a salt-shock-induced protein. Two identical monomers form a cylindrically shaped dimer in which six helices are located on the inside and two six-stranded beta-sheets wrap around these helices. Structural comparison suggests that the OsmC sequence family has a peroxiredoxin function and has a unique structure compared with other peroxiredoxin families. A detailed analysis of structures and sequence comparisons in the OsmC sequence family revealed that each subfamily has unique motifs. In addition, the molecular function of the OsmC sequence family is discussed based on structural comparisons among the subfamily members.
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<StructureSection load='1nye' size='340' side='right'caption='[[1nye]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1nye]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NYE FirstGlance]. <br>
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1NYE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYE OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nye OCA], [https://pdbe.org/1nye PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nye RCSB], [https://www.ebi.ac.uk/pdbsum/1nye PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nye ProSAT], [https://www.topsan.org/Proteins/BSGC/1nye TOPSAN]</span></td></tr>
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==Reference==
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</table>
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Structure of OsmC from Escherichia coli: a salt-shock-induced protein., Shin DH, Choi IG, Busso D, Jancarik J, Yokota H, Kim R, Kim SH, Acta Crystallogr D Biol Crystallogr. 2004 May;60(Pt 5):903-11. Epub 2004, Apr 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15103136 15103136]
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== Function ==
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[https://www.uniprot.org/uniprot/OSMC_ECOLI OSMC_ECOLI] Preferentially metabolizes organic hydroperoxides over inorganic hydrogen peroxide.<ref>PMID:14627744</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ny/1nye_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nye ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: BSGC, Berkeley Structural Genomics Center.]]
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[[Category: Busso D]]
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[[Category: Busso, D.]]
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[[Category: Choi I-G]]
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[[Category: Choi, I G.]]
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[[Category: Jancarik J]]
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[[Category: Jancarik, J.]]
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[[Category: Kim R]]
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[[Category: Kim, R.]]
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[[Category: Kim S-H]]
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[[Category: Kim, S H.]]
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[[Category: Shin DH]]
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[[Category: Shin, D H.]]
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[[Category: Yokota H]]
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[[Category: Yokota, H.]]
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[[Category: berkeley structural genomics center]]
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[[Category: bsgc structure funded by nih]]
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[[Category: crystal structure]]
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[[Category: osmc]]
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[[Category: peroxiredoxin]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: structural genomics]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:11:24 2008''
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Current revision

Crystal structure of OsmC from E. coli

PDB ID 1nye

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