1af8

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[[Image:1af8.gif|left|200px]]<br />
 
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<applet load="1af8" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1af8" />
 
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'''ACTINORHODIN POLYKETIDE SYNTHASE ACYL CARRIER PROTEIN FROM STREPTOMYCES COELICOLOR A3(2), NMR, 24 STRUCTURES'''<br />
 
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==Overview==
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==ACTINORHODIN POLYKETIDE SYNTHASE ACYL CARRIER PROTEIN FROM STREPTOMYCES COELICOLOR A3(2), NMR, 24 STRUCTURES==
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The solution structure of the actinorhodin acyl carrier protein (act, apo-ACP) from the polyketide synthase (PKS) of Streptomyces coelicolor, A3(2) has been determined using 1H NMR spectroscopy, representing the, first polyketide synthase component for which detailed structural, information has been obtained. Twenty-four structures were generated by, simulated annealing, employing 699 distance restraints and 94 dihedral, angle restraints. The structure is composed, principally, of three major, helices (1, 2, and 4), a shorter helix (3) and a large loop region, separating helices 1 and 2. The structure is well-defined, except for a, portion of the loop region (residues 18-29), the N-terminus (1-4), and a, short stretch (57-61) in the loop connecting helices 2 and 3. The RMS, distribution ... [[http://ispc.weizmann.ac.il/pmbin/getpm?9166770 (full description)]]
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<StructureSection load='1af8' size='340' side='right'caption='[[1af8]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1af8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_coelicolor_A3(2) Streptomyces coelicolor A3(2)]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AF8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1af8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1af8 OCA], [https://pdbe.org/1af8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1af8 RCSB], [https://www.ebi.ac.uk/pdbsum/1af8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1af8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACPX_STRCO ACPX_STRCO] Acyl carrier protein.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/af/1af8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1af8 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1AF8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]]. Structure known Active Site: S42. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AF8 OCA]].
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*[[Acyl carrier protein synthase 3D structures|Acyl carrier protein synthase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Solution structure of the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2)., Crump MP, Crosby J, Dempsey CE, Parkinson JA, Murray M, Hopwood DA, Simpson TJ, Biochemistry. 1997 May 20;36(20):6000-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9166770 9166770]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Crosby J]]
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[[Category: Streptomyces coelicolor]]
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[[Category: Crump MP]]
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[[Category: Crosby, J.]]
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[[Category: Dempsey CE]]
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[[Category: Crump, M.P.]]
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[[Category: Hopwood DA]]
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[[Category: Dempsey, C.E.]]
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[[Category: Murray M]]
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[[Category: Hopwood, D.A.]]
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[[Category: Parkinson JA]]
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[[Category: Murray, M.]]
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[[Category: Simpson TJ]]
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[[Category: Parkinson, J.A.]]
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[[Category: Simpson, T.J.]]
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[[Category: acyl carrier protein]]
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[[Category: antibiotic biosynthesis]]
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[[Category: nmr structure]]
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[[Category: polyketide]]
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[[Category: solution structure]]
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[[Category: streptomyces]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:47:47 2007''
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Current revision

ACTINORHODIN POLYKETIDE SYNTHASE ACYL CARRIER PROTEIN FROM STREPTOMYCES COELICOLOR A3(2), NMR, 24 STRUCTURES

PDB ID 1af8

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