1yax

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[[Image:1yax.png|left|200px]]
 
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{{STRUCTURE_1yax| PDB=1yax | SCENE= }}
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==Cystal structure Analysis of S.typhimurium PhoQ sensor domain with Calcium==
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<StructureSection load='1yax' size='340' side='right'caption='[[1yax]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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===Cystal structure Analysis of S.typhimurium PhoQ sensor domain with Calcium===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1yax]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YAX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YAX FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16406409}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yax OCA], [https://pdbe.org/1yax PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yax RCSB], [https://www.ebi.ac.uk/pdbsum/1yax PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yax ProSAT]</span></td></tr>
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[[1yax]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YAX OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PHOQ_SALTY PHOQ_SALTY] Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence, adaptation to acidic and low Mg(2+) environments and resistance to host defense antimicrobial peptides. Essential for intramacrophage survival of S.typhimurium. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phospho-PhoP, resulting in the repression of PAG and may lead to expression of some PRG. Essential for transcription of spiC inside macrophages by controlling the expression of the two-component regulatory system SsrB/SpiR (SsrA) and Pir at transcriptional and post-transcriptional levels respectively. Promotes expression of the two-component regulatory system PmrA/PmrB via activation of pmrD gene. Is required to attenuate bacterial growth within fibroblast cells and to enhance bacterial resistance to bile in intestinal cells. Negatively regulates prgH, which is required for invasion of epithelial cells. Involved in acid tolerance.<ref>PMID:2544889</ref> <ref>PMID:9573193</ref> <ref>PMID:15910283</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ya/1yax_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yax ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[PhoP-PhoQ|PhoP-PhoQ]]
*[[PhoP-PhoQ|PhoP-PhoQ]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016406409</ref><ref group="xtra">PMID:016096064</ref><references group="xtra"/>
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__TOC__
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[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
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</StructureSection>
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[[Category: Cho, U S.]]
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[[Category: Large Structures]]
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[[Category: Xu, W.]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
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[[Category: Magnesium/calcium bound]]
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[[Category: Cho US]]
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[[Category: Magnesium/calcium sensor]]
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[[Category: Xu W]]
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[[Category: Phoq]]
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[[Category: Sensor domain]]
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[[Category: Signaling protein]]
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[[Category: Transferase]]
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Current revision

Cystal structure Analysis of S.typhimurium PhoQ sensor domain with Calcium

PDB ID 1yax

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