3bkd
From Proteopedia
(Difference between revisions)
| (6 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:3bkd.png|left|200px]] | ||
| - | + | ==High resolution Crystal structure of Transmembrane domain of M2 protein== | |
| - | + | <StructureSection load='3bkd' size='340' side='right'caption='[[3bkd]], [[Resolution|resolution]] 2.05Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3bkd]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Chicken/Hong_Kong/G23/97(H9N2)) Influenza A virus (A/Chicken/Hong Kong/G23/97(H9N2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BKD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BKD FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bkd OCA], [https://pdbe.org/3bkd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bkd RCSB], [https://www.ebi.ac.uk/pdbsum/3bkd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bkd ProSAT]</span></td></tr> |
| - | [[3bkd]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BKD OCA]. | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q9Q0P0_9INFA Q9Q0P0_9INFA] Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.[RuleBase:RU361247] Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.[SAAS:SAAS00108379] | ||
==See Also== | ==See Also== | ||
| - | + | *[[Ion channels 3D structures|Ion channels 3D structures]] | |
| - | *[[Ion channels|Ion channels]] | + | |
*[[M2 protein|M2 protein]] | *[[M2 protein|M2 protein]] | ||
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
| - | + | [[Category: Acharya R]] | |
| - | [[Category: | + | [[Category: Salom D]] |
| - | [[Category: | + | [[Category: Stouffer AL]] |
| - | [[Category: | + | |
| - | [[Category: | + | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
High resolution Crystal structure of Transmembrane domain of M2 protein
| |||||||||||
