4e74

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[[Image:4e74.png|left|200px]]
 
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{{STRUCTURE_4e74| PDB=4e74 | SCENE= }}
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==Crystal structure of the RHO GTPASE BINDING DOMAIN of Plexin A4A==
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<StructureSection load='4e74' size='340' side='right'caption='[[4e74]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
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===Crystal structure of the RHO GTPASE BINDING DOMAIN of Plexin A4A===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4e74]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E74 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E74 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58&#8491;</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e74 OCA], [https://pdbe.org/4e74 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e74 RCSB], [https://www.ebi.ac.uk/pdbsum/4e74 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e74 ProSAT]</span></td></tr>
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[[4e74]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E74 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PLXA4_HUMAN PLXA4_HUMAN] Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).
==See Also==
==See Also==
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*[[Plexin|Plexin]]
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*[[Plexin 3D structures|Plexin 3D structures]]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bountra, C.]]
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[[Category: Arrowsmith CH]]
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[[Category: Dong, A.]]
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[[Category: Bountra C]]
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[[Category: Edwards, A M.]]
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[[Category: Dong A]]
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[[Category: Guan, X.]]
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[[Category: Edwards AM]]
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[[Category: Park, H.]]
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[[Category: Guan X]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Park H]]
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[[Category: Tempel, W.]]
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[[Category: Tempel W]]
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[[Category: Tong, Y.]]
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[[Category: Tong Y]]
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[[Category: Wang, H.]]
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[[Category: Wang H]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Plexin]]
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[[Category: Rbd]]
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[[Category: Sgc]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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Current revision

Crystal structure of the RHO GTPASE BINDING DOMAIN of Plexin A4A

PDB ID 4e74

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