2d7h

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[[Image:2d7h.png|left|200px]]
 
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{{STRUCTURE_2d7h| PDB=2d7h | SCENE= }}
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==Crystal structure of the ccc complex of the N-terminal domain of PriA==
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<StructureSection load='2d7h' size='340' side='right'caption='[[2d7h]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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===Crystal structure of the ccc complex of the N-terminal domain of PriA===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2d7h]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D7H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D7H FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16226927}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d7h OCA], [https://pdbe.org/2d7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d7h RCSB], [https://www.ebi.ac.uk/pdbsum/2d7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d7h ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[2d7h]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D7H OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/PRIA_ECOLI PRIA_ECOLI] Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA. Is also involved in initiation of normal DNA replication in various plasmids and phages. Binds to branched DNA structures that resemble D-loops or to the primosome assembly site (PAS). Binds to DNA in two distinct modes, either dependent on or independent of the 3' terminus recognition.<ref>PMID:2825188</ref> <ref>PMID:8366072</ref> <ref>PMID:10356325</ref> <ref>PMID:10956036</ref> <ref>PMID:11929519</ref> <ref>PMID:12622722</ref> <ref>PMID:12917421</ref> <ref>PMID:15576682</ref> <ref>PMID:17483094</ref> <ref>PMID:23264623</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d7/2d7h_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d7h ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Helicase|Helicase]]
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*[[Helicase 3D structures|Helicase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016226927</ref><references group="xtra"/>
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__TOC__
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[[Category: Escherichia coli]]
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</StructureSection>
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[[Category: Kohda, D.]]
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[[Category: Escherichia coli K-12]]
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[[Category: Maenaka, K.]]
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[[Category: Large Structures]]
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[[Category: Masai, H.]]
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[[Category: Synthetic construct]]
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[[Category: Ose, T.]]
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[[Category: Kohda D]]
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[[Category: Sasaki, K.]]
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[[Category: Maenaka K]]
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[[Category: Hydrolase]]
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[[Category: Masai H]]
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[[Category: Protein-dna complex]]
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[[Category: Ose T]]
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[[Category: Sasaki K]]

Current revision

Crystal structure of the ccc complex of the N-terminal domain of PriA

PDB ID 2d7h

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