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1huz

From Proteopedia

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[[Image:1huz.png|left|200px]]
 
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{{STRUCTURE_1huz| PDB=1huz | SCENE= }}
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==CRYSTAL STRUCTURE OF DNA POLYMERASE COMPLEXED WITH DNA AND CR-PCP==
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<StructureSection load='1huz' size='340' side='right'caption='[[1huz]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF DNA POLYMERASE COMPLEXED WITH DNA AND CR-PCP===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1huz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HUZ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11330999}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CR:CHROMIUM+ION'>CR</scene>, <scene name='pdbligand=MDN:METHYLENEDIPHOSPHONIC+ACID'>MDN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1huz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1huz OCA], [https://pdbe.org/1huz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1huz RCSB], [https://www.ebi.ac.uk/pdbsum/1huz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1huz ProSAT]</span></td></tr>
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[[1huz]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HUZ OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DPOLB_RAT DPOLB_RAT] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hu/1huz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1huz ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[DNA polymerase|DNA polymerase]]
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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*[[Z-DNA|Z-DNA]]
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==Reference==
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__TOC__
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<ref group="xtra">PMID:011330999</ref><references group="xtra"/>
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</StructureSection>
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Arndt, J W.]]
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[[Category: Arndt JW]]
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[[Category: Chan, M K.]]
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[[Category: Chan MK]]
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[[Category: Gong, W.]]
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[[Category: Gong W]]
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[[Category: Lin, Z.]]
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[[Category: Lin Z]]
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[[Category: Liu, J.]]
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[[Category: Liu J]]
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[[Category: Paxson, C.]]
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[[Category: Paxson C]]
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[[Category: Showalter, A K.]]
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[[Category: Showalter AK]]
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[[Category: Tsai, M D.]]
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[[Category: Tsai M-D]]
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[[Category: Zhong, X.]]
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[[Category: Zhong X]]
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[[Category: Protein-dna complex]]
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[[Category: Transferase-dna complex]]
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Current revision

CRYSTAL STRUCTURE OF DNA POLYMERASE COMPLEXED WITH DNA AND CR-PCP

PDB ID 1huz

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