3itm

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[[Image:3itm.png|left|200px]]
 
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{{STRUCTURE_3itm| PDB=3itm | SCENE= }}
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==Catalytic domain of hPDE2A==
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<StructureSection load='3itm' size='340' side='right'caption='[[3itm]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
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===Catalytic domain of hPDE2A===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3itm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ITM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ITM FirstGlance]. <br>
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{{ABSTRACT_PUBMED_19828435}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.49&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3itm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3itm OCA], [https://pdbe.org/3itm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3itm RCSB], [https://www.ebi.ac.uk/pdbsum/3itm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3itm ProSAT]</span></td></tr>
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[[3itm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ITM OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE2A_HUMAN PDE2A_HUMAN] Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.<ref>PMID:15938621</ref> <ref>PMID:19828435</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/it/3itm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3itm ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Phosphodiesterase|Phosphodiesterase]]
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019828435</ref><references group="xtra"/>
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__TOC__
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[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Pandit, J.]]
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[[Category: Large Structures]]
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[[Category: All-alpha helical]]
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[[Category: Pandit J]]
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[[Category: Cgmp]]
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[[Category: Hydrolase]]
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[[Category: Membrane]]
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[[Category: Zn-binding]]
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Current revision

Catalytic domain of hPDE2A

PDB ID 3itm

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