3s54

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[[Image:3s54.png|left|200px]]
 
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{{STRUCTURE_3s54| PDB=3s54 | SCENE= }}
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==HIV-1 protease triple mutants V32I, I47V, V82I with antiviral drug darunavir in space group P21212==
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<StructureSection load='3s54' size='340' side='right'caption='[[3s54]], [[Resolution|resolution]] 1.42&Aring;' scene=''>
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===HIV-1 protease triple mutants V32I, I47V, V82I with antiviral drug darunavir in space group P21212===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3s54]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S54 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S54 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22238126}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.42&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=017:(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE'>017</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s54 OCA], [https://pdbe.org/3s54 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s54 RCSB], [https://www.ebi.ac.uk/pdbsum/3s54 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s54 ProSAT]</span></td></tr>
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[[3s54]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S54 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q7SSI0_9HIV1 Q7SSI0_9HIV1]
==See Also==
==See Also==
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*[[Virus protease|Virus protease]]
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*[[Immunodeficiency virus protease 3D structures|Immunodeficiency virus protease 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:022238126</ref><references group="xtra"/>
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[[Category: HIV-1 retropepsin]]
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[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: Tie, Y F.]]
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[[Category: Large Structures]]
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[[Category: Wang, Y F.]]
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[[Category: Tie Y-F]]
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[[Category: Weber, I T.]]
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[[Category: Wang Y-F]]
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[[Category: Aspartic protease]]
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[[Category: Weber IT]]
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[[Category: Darunavir]]
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[[Category: Drug resistance]]
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[[Category: Hiv/aid]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Molecular recognition]]
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Current revision

HIV-1 protease triple mutants V32I, I47V, V82I with antiviral drug darunavir in space group P21212

PDB ID 3s54

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