1wwf

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[[Image:1wwf.png|left|200px]]
 
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{{STRUCTURE_1wwf| PDB=1wwf | SCENE= }}
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==NMR Structure Determined for MLV NC Complex with RNA Sequence CCUCCGU==
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<StructureSection load='1wwf' size='340' side='right'caption='[[1wwf]]' scene=''>
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===NMR Structure Determined for MLV NC Complex with RNA Sequence CCUCCGU===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1wwf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Moloney_murine_leukemia_virus Moloney murine leukemia virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WWF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WWF FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15751950}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wwf OCA], [https://pdbe.org/1wwf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wwf RCSB], [https://www.ebi.ac.uk/pdbsum/1wwf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wwf ProSAT]</span></td></tr>
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[[1wwf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Moloney_murine_leukemia_virus Moloney murine leukemia virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WWF OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GAG_MLVMS GAG_MLVMS] Gag polyprotein plays a role in budding and is processed by the viral protease during virion maturation outside the cell. During budding, it recruits, in a PPXY-dependent or independent manner, Nedd4-like ubiquitin ligases that conjugate ubiquitin molecules to Gag, or to Gag binding host factors. Interaction with HECT ubiquitin ligases probably link the viral protein to the host ESCRT pathway and facilitate release.<ref>PMID:19864377</ref> Matrix protein p15 targets Gag and gag-pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex (By similarity).<ref>PMID:19864377</ref> Capsid protein p30 forms the spherical core of the virion that encapsulates the genomic RNA-nucleocapsid complex (By similarity).<ref>PMID:19864377</ref> Nucleocapsid protein p10 is involved in the packaging and encapsidation of two copies of the genome. Binds with high affinity to conserved UCUG elements within the packaging signal, located near the 5'-end of the genome. This binding is dependent on genome dimerization.<ref>PMID:19864377</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ww/1wwf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wwf ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Nucleoprotein|Nucleoprotein]]
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:015751950</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Moloney murine leukemia virus]]
[[Category: Moloney murine leukemia virus]]
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[[Category: Dey, A.]]
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[[Category: Dey A]]
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[[Category: Smalls-Mantey, A.]]
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[[Category: Smalls-Mantey A]]
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[[Category: Summers, M F.]]
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[[Category: Summers MF]]
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[[Category: York, D.]]
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[[Category: York D]]
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[[Category: Hydrophobic guanosine binding pocket]]
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[[Category: Viral protein-rna complex]]
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Current revision

NMR Structure Determined for MLV NC Complex with RNA Sequence CCUCCGU

PDB ID 1wwf

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