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3bp6

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[[Image:3bp6.png|left|200px]]
 
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{{STRUCTURE_3bp6| PDB=3bp6 | SCENE= }}
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==Crystal structure of the mouse PD-1 Mutant and PD-L2 complex==
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<StructureSection load='3bp6' size='340' side='right'caption='[[3bp6]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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===Crystal structure of the mouse PD-1 Mutant and PD-L2 complex===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3bp6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BP6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BP6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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[[3bp6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BP6 OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bp6 OCA], [https://pdbe.org/3bp6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bp6 RCSB], [https://www.ebi.ac.uk/pdbsum/3bp6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bp6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDCD1_MOUSE PDCD1_MOUSE] Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bp/3bp6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bp6 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Cell death protein|Cell death protein]]
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*[[Cell death protein 3D structures|Cell death protein 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Almo, S C.]]
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[[Category: Almo SC]]
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[[Category: Cao, E.]]
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[[Category: Cao E]]
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[[Category: Lazar-Molnar, E.]]
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[[Category: Lazar-Molnar E]]
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[[Category: Nathenson, S G.]]
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[[Category: Nathenson SG]]
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[[Category: Ramagopal, U A.]]
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[[Category: Ramagopal UA]]
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[[Category: Toro, R.]]
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[[Category: Toro R]]
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[[Category: Yan, Q.]]
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[[Category: Yan Q]]
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[[Category: Complex]]
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[[Category: Costimulation]]
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[[Category: Glycoprotein]]
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[[Category: Immunoglobulin domain]]
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[[Category: Membrane]]
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[[Category: Pd-1]]
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[[Category: Pd-l2]]
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[[Category: Receptor]]
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[[Category: Signaling protein]]
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[[Category: Transmembrane]]
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Current revision

Crystal structure of the mouse PD-1 Mutant and PD-L2 complex

PDB ID 3bp6

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