This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2ano

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:13, 14 February 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2ano.png|left|200px]]
 
-
{{STRUCTURE_2ano| PDB=2ano | SCENE= }}
+
==Crystal structure of E.coli dihydrofolate reductase in complex with NADPH and the inhibitor MS-SH08-17==
-
 
+
<StructureSection load='2ano' size='340' side='right'caption='[[2ano]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
-
===Crystal structure of E.coli dihydrofolate reductase in complex with NADPH and the inhibitor MS-SH08-17===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[2ano]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ANO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ANO FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_17125251}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.68&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=817:1-{[N-(1-IMINO-GUANIDINO-METHYL)]SULFANYLMETHYL}-3-TRIFLUOROMETHYL-BENZENE'>817</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ano FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ano OCA], [https://pdbe.org/2ano PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ano RCSB], [https://www.ebi.ac.uk/pdbsum/2ano PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ano ProSAT]</span></td></tr>
-
[[2ano]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ANO OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/an/2ano_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ano ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Dihydrofolate reductase|Dihydrofolate reductase]]
+
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:017125251</ref><ref group="xtra">PMID:016126221</ref><references group="xtra"/>
+
-
[[Category: Dihydrofolate reductase]]
+
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
-
[[Category: Brown, E D.]]
+
[[Category: Large Structures]]
-
[[Category: Daigle, D M.]]
+
[[Category: Brown ED]]
-
[[Category: Hughes, D W.]]
+
[[Category: Daigle DM]]
-
[[Category: Jackson, S G.]]
+
[[Category: Hughes DW]]
-
[[Category: Junop, M S.]]
+
[[Category: Jackson SG]]
-
[[Category: Mayer, S.]]
+
[[Category: Junop MS]]
-
[[Category: Organ, M.]]
+
[[Category: Mayer S]]
-
[[Category: Summerfield, R L.]]
+
[[Category: Organ M]]
-
[[Category: Dhfr]]
+
[[Category: Summerfield RL]]
-
[[Category: Oxidoreductase]]
+
-
[[Category: Protein inhibitor complex]]
+

Current revision

Crystal structure of E.coli dihydrofolate reductase in complex with NADPH and the inhibitor MS-SH08-17

PDB ID 2ano

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ano"
Personal tools