3bm9

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[[Image:3bm9.png|left|200px]]
 
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{{STRUCTURE_3bm9| PDB=3bm9 | SCENE= }}
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==Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90==
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<StructureSection load='3bm9' size='340' side='right'caption='[[3bm9]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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===Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3bm9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BM9 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_18197612}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BXZ:4-BROMO-6-(6-HYDROXY-1,2-BENZISOXAZOL-3-YL)BENZENE-1,3-DIOL'>BXZ</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bm9 OCA], [https://pdbe.org/3bm9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bm9 RCSB], [https://www.ebi.ac.uk/pdbsum/3bm9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bm9 ProSAT]</span></td></tr>
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[[3bm9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BM9 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bm/3bm9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bm9 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Heat Shock Proteins|Heat Shock Proteins]]
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018197612</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arndt, K.]]
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[[Category: Large Structures]]
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[[Category: Boschelli, F.]]
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[[Category: Arndt K]]
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[[Category: Chopra, R.]]
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[[Category: Boschelli F]]
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[[Category: Ellingboe, J.]]
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[[Category: Chopra R]]
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[[Category: Golas, J.]]
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[[Category: Ellingboe J]]
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[[Category: Gopalsamy, A.]]
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[[Category: Golas J]]
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[[Category: Jacob, J.]]
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[[Category: Gopalsamy A]]
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[[Category: Johnson, J.]]
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[[Category: Jacob J]]
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[[Category: Lee, F.]]
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[[Category: Johnson J]]
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[[Category: Nilakantan, R.]]
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[[Category: Lee F]]
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[[Category: Peterson, R.]]
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[[Category: Nilakantan R]]
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[[Category: Shi, M.]]
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[[Category: Peterson R]]
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[[Category: Svenson, K.]]
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[[Category: Shi M]]
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[[Category: Tam, M S.]]
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[[Category: Svenson K]]
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[[Category: Vogan, E M.]]
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[[Category: Tam MS]]
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[[Category: Wen, Y.]]
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[[Category: Vogan EM]]
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[[Category: Atp binding domain]]
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[[Category: Wen Y]]
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[[Category: Atp-binding]]
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[[Category: Chaperone]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Stress response]]
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Current revision

Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90

PDB ID 3bm9

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Proteopedia Page Contributors and Editors (what is this?)

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