1q0y

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[[Image:1q0y.png|left|200px]]
 
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{{STRUCTURE_1q0y| PDB=1q0y | SCENE= }}
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==Anti-Morphine Antibody 9B1 Complexed with Morphine==
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<StructureSection load='1q0y' size='340' side='right'caption='[[1q0y]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1q0y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q0Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q0Y FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MOI:(7R,7AS,12BS)-3-METHYL-2,3,4,4A,7,7A-HEXAHYDRO-1H-4,12-METHANO[1]BENZOFURO[3,2-E]ISOQUINOLINE-7,9-DIOL'>MOI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q0y OCA], [https://pdbe.org/1q0y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q0y RCSB], [https://www.ebi.ac.uk/pdbsum/1q0y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q0y ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LV1B_MOUSE LV1B_MOUSE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q0/1q0y_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q0y ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structures of an anti-morphine antibody 9B1 (to 1.6A resolution) and its complex with morphine (to 2.0 A resolution) are reported. The morphine-binding site is described as a shallow depression on the protein surface, an unusual topology for a high-affinity ( Ka approximately 10(9) M(-1)) antibody against a small antigen. The polar part of the ligand is exposed to solvent, and the cationic nitrogen atom of the morphine molecule is anchored at the bottom of the binding site by a salt-bridge to a glutamate side-chain. Additional affinity is provided by a double cation-pi interaction with two tryptophan residues. Comparison of the morphine complex with the structure of the free Fab shows that a domain closure occurs upon binding of the ligand.
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===Anti-Morphine Antibody 9B1 Complexed with Morphine===
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Anchoring a cationic ligand: the structure of the Fab fragment of the anti-morphine antibody 9B1 and its complex with morphine.,Pozharski E, Wilson MA, Hewagama A, Shanafelt AB, Petsko G, Ringe D J Mol Biol. 2004 Mar 26;337(3):691-7. PMID:15019787<ref>PMID:15019787</ref>
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{{ABSTRACT_PUBMED_15019787}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1q0y" style="background-color:#fffaf0;"></div>
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[[1q0y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q0Y OCA].
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==See Also==
==See Also==
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*[[Antibody|Antibody]]
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[3D structures of non-human antibody|3D structures of non-human antibody]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:015019787</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Hewagama, A.]]
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[[Category: Hewagama A]]
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[[Category: Petsko, G.]]
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[[Category: Petsko G]]
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[[Category: Pozharski, E.]]
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[[Category: Pozharski E]]
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[[Category: Ringe, D.]]
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[[Category: Ringe D]]
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[[Category: Shanafelt, A B.]]
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[[Category: Shanafelt AB]]
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[[Category: Wilson, M A.]]
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[[Category: Wilson MA]]
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[[Category: Anti-morphine antibody]]
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[[Category: Fab]]
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[[Category: Immune system]]
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Current revision

Anti-Morphine Antibody 9B1 Complexed with Morphine

PDB ID 1q0y

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