1k0d

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[[Image:1k0d.png|left|200px]]
 
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{{STRUCTURE_1k0d| PDB=1k0d | SCENE= }}
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==Ure2p in Complex with Glutathione==
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<StructureSection load='1k0d' size='340' side='right'caption='[[1k0d]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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===Ure2p in Complex with Glutathione===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1k0d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K0D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K0D FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11695904}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k0d OCA], [https://pdbe.org/1k0d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k0d RCSB], [https://www.ebi.ac.uk/pdbsum/1k0d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k0d ProSAT]</span></td></tr>
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[[1k0d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K0D OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/URE2_YEAST URE2_YEAST] Plays an important role in nitrogen catabolite repression. Down-regulates the expression of many genes involved in nitrogen utilization by inhibiting the GATA transcriptional activators GLN3 and GAT1. Under good nitrogen conditions, binds to the phosphorylated forms of GLN3 and GAT1 and sequesters them in the cytoplasm, preventing transcription of genes expressed upon nitrogen limitation. Is also an atypical glutaredoxin without a catalytical cysteine residue. Has glutathione peroxidase and thiol:disulfide oxidoreductase activities in both native and fibrillar form. Also shows insulin disulfide reductase and dehydroascorbic acid reductase (DHAR) actvites.<ref>PMID:1990286</ref> <ref>PMID:8755910</ref> <ref>PMID:10604478</ref> <ref>PMID:10799523</ref> <ref>PMID:15371425</ref> <ref>PMID:19321443</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k0/1k0d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k0d ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Prion|Prion]]
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*[[Prion 3D structures|Prion 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:011695904</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Belrhali, H.]]
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[[Category: Belrhali H]]
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[[Category: Bousset, L.]]
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[[Category: Bousset L]]
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[[Category: Melki, R.]]
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[[Category: Melki R]]
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[[Category: Morera, S.]]
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[[Category: Morera S]]
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[[Category: Gene regulation]]
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[[Category: Nitrate assimilation]]
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[[Category: Structural genomic]]
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Current revision

Ure2p in Complex with Glutathione

PDB ID 1k0d

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