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2euf

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[[Image:2euf.png|left|200px]]
 
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{{STRUCTURE_2euf| PDB=2euf | SCENE= }}
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==X-ray structure of human CDK6-Vcyclin in complex with the inhibitor PD0332991==
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<StructureSection load='2euf' size='340' side='right'caption='[[2euf]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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===X-ray structure of human CDK6-Vcyclin in complex with the inhibitor PD0332991===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2euf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Herpesvirus_saimiri_(strain_11) Herpesvirus saimiri (strain 11)] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EUF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EUF FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16789739}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=LQQ:6-ACETYL-8-CYCLOPENTYL-5-METHYL-2-[(5-PIPERAZIN-1-YLPYRIDIN-2-YL)AMINO]PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE'>LQQ</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2euf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2euf OCA], [https://pdbe.org/2euf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2euf RCSB], [https://www.ebi.ac.uk/pdbsum/2euf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2euf ProSAT]</span></td></tr>
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[[2euf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EUF OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CGH2_SHV21 CGH2_SHV21] May be highly relevant to the process of cellular transformation and rapid T-cell proliferation effected by HVS during latent infections of T-cells in susceptible hosts.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eu/2euf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2euf ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Cyclin|Cyclin]]
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*[[Cyclin 3D structures|Cyclin 3D structures]]
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*[[Cyclin-dependent kinase 3D structures|Cyclin-dependent kinase 3D structures]]
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==Reference==
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__TOC__
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<ref group="xtra">PMID:016789739</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Viruses]]
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[[Category: Lu H]]
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[[Category: Lu, H.]]
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[[Category: Schulze-Gahmen U]]
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[[Category: Schulze-Gahmen, U.]]
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[[Category: Cell cycle-transferase complex]]
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[[Category: Inhibitor complex of human cyclin-dependent kinase 6]]
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Current revision

X-ray structure of human CDK6-Vcyclin in complex with the inhibitor PD0332991

PDB ID 2euf

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