2zq9

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[[Image:2zq9.png|left|200px]]
 
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{{STRUCTURE_2zq9| PDB=2zq9 | SCENE= }}
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==Cephalothin acyl-intermediate structure of class a beta-lactamase Toho-1 E166A/R274N/R276N triple mutant==
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<StructureSection load='2zq9' size='340' side='right'caption='[[2zq9]], [[Resolution|resolution]] 1.07&Aring;' scene=''>
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===Cephalothin acyl-intermediate structure of class a beta-lactamase Toho-1 E166A/R274N/R276N triple mutant===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2zq9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZQ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZQ9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.07&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CEO:5-METHYLENE-2-[2-OXO-1-(2-THIOPHEN-2-YL-ACETYLAMINO)-ETHYL]-5,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC+ACID'>CEO</scene>, <scene name='pdbligand=CLS:CEPHALOTHIN'>CLS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SPA:THIOPHENEACETIC+ACID'>SPA</scene></td></tr>
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[[2zq9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZQ9 OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zq9 OCA], [https://pdbe.org/2zq9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zq9 RCSB], [https://www.ebi.ac.uk/pdbsum/2zq9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zq9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BLT1_ECOLX BLT1_ECOLX] Has strong cefotaxime-hydrolyzing activity.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zq/2zq9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zq9 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Beta-lactamase|Beta-lactamase]]
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
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[[Category: Beta-lactamase]]
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Ishii, Y.]]
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[[Category: Large Structures]]
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[[Category: Matsuzawa, H.]]
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[[Category: Ishii Y]]
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[[Category: Miyano, M.]]
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[[Category: Matsuzawa H]]
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[[Category: Nitanai, Y.]]
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[[Category: Miyano M]]
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[[Category: Shimamura, T.]]
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[[Category: Nitanai Y]]
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[[Category: Takehira, M.]]
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[[Category: Shimamura T]]
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[[Category: Uchiyama, T.]]
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[[Category: Takehira M]]
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[[Category: Yutani, K.]]
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[[Category: Uchiyama T]]
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[[Category: Acyl-enzyme]]
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[[Category: Yutani K]]
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[[Category: Antibiotic resistance]]
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[[Category: Beta-lactamase]]
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[[Category: Cephalothin]]
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[[Category: Complex]]
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[[Category: Esbl]]
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[[Category: Extended-spectrum]]
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[[Category: Hydrolase]]
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[[Category: Toho-1]]
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Current revision

Cephalothin acyl-intermediate structure of class a beta-lactamase Toho-1 E166A/R274N/R276N triple mutant

PDB ID 2zq9

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