1mf4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:35, 10 April 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1mf4.png|left|200px]]
 
-
{{STRUCTURE_1mf4| PDB=1mf4 | SCENE= }}
+
==Structure-based design of potent and selective inhibitors of phospholipase A2: Crystal structure of the complex formed between phosholipase A2 from Naja Naja sagittifera and a designed peptide inhibitor at 1.9 A resolution==
-
 
+
<StructureSection load='1mf4' size='340' side='right'caption='[[1mf4]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-
===Structure-based design of potent and selective inhibitors of phospholipase A2: Crystal structure of the complex formed between phosholipase A2 from Naja Naja sagittifera and a designed peptide inhibitor at 1.9 A resolution===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1mf4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_sagittifera Naja sagittifera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MF4 FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_14529280}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mf4 OCA], [https://pdbe.org/1mf4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mf4 RCSB], [https://www.ebi.ac.uk/pdbsum/1mf4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mf4 ProSAT]</span></td></tr>
-
[[1mf4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_sagittifera Naja sagittifera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MF4 OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PA2A3_NAJSG PA2A3_NAJSG] PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mf/1mf4_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mf4 ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Phospholipase A2|Phospholipase A2]]
+
*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:014529280</ref><references group="xtra"/>
+
[[Category: Large Structures]]
[[Category: Naja sagittifera]]
[[Category: Naja sagittifera]]
-
[[Category: Dey, S.]]
+
[[Category: Dey S]]
-
[[Category: Jabeen, T.]]
+
[[Category: Jabeen T]]
-
[[Category: Kaur, P.]]
+
[[Category: Kaur P]]
-
[[Category: Makker, J.]]
+
[[Category: Makker J]]
-
[[Category: Paramsivam, M.]]
+
[[Category: Paramsivam M]]
-
[[Category: Sharma, S.]]
+
[[Category: Sharma S]]
-
[[Category: Singh, R K.]]
+
[[Category: Singh RK]]
-
[[Category: Singh, T P.]]
+
[[Category: Singh TP]]
-
[[Category: Srinivasan, A.]]
+
[[Category: Srinivasan A]]
-
[[Category: Vikram, P.]]
+
[[Category: Vikram P]]
-
[[Category: Designed inhibitor]]
+
-
[[Category: Hydrolase-hydrolase inhibitor complex]]
+
-
[[Category: Naja naja sagittifera]]
+
-
[[Category: Phospholipase a2]]
+

Current revision

Structure-based design of potent and selective inhibitors of phospholipase A2: Crystal structure of the complex formed between phosholipase A2 from Naja Naja sagittifera and a designed peptide inhibitor at 1.9 A resolution

PDB ID 1mf4

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mf4"
Personal tools