3hw8

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[[Image:3hw8.png|left|200px]]
 
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{{STRUCTURE_3hw8| PDB=3hw8 | SCENE= }}
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==ternary complex of DNA polymerase lambda of a two nucleotide gapped DNA substrate with a C in the scrunch site==
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<StructureSection load='3hw8' size='340' side='right'caption='[[3hw8]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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===ternary complex of DNA polymerase lambda of a two nucleotide gapped DNA substrate with a C in the scrunch site===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3hw8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HW8 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_019701199}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D3T:2,3-DIDEOXY-THYMIDINE-5-TRIPHOSPHATE'>D3T</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hw8 OCA], [https://pdbe.org/3hw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hw8 RCSB], [https://www.ebi.ac.uk/pdbsum/3hw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hw8 ProSAT]</span></td></tr>
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[[3hw8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HW8 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DPOLL_HUMAN DPOLL_HUMAN] Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.<ref>PMID:11457865</ref> <ref>PMID:15537631</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hw/3hw8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hw8 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[DNA polymerase|DNA polymerase]]
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019701199</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bebenek, K.]]
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[[Category: Large Structures]]
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[[Category: Garcia-Diaz, M.]]
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[[Category: Bebenek K]]
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[[Category: Havener, J M.]]
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[[Category: Garcia-Diaz M]]
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[[Category: Krahn, J M.]]
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[[Category: Havener JM]]
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[[Category: Kunkel, T A.]]
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[[Category: Krahn JM]]
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[[Category: Larrea, A A.]]
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[[Category: Kunkel TA]]
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[[Category: Pedersen, L C.]]
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[[Category: Larrea AA]]
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[[Category: Perera, L.]]
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[[Category: Pedersen LC]]
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[[Category: Ramsden, D A.]]
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[[Category: Perera L]]
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[[Category: Dna damage]]
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[[Category: Ramsden DA]]
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[[Category: Dna repair]]
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[[Category: Dna replication]]
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[[Category: Dna synthesis]]
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[[Category: Dna-binding]]
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[[Category: Dna-directed dna polymerase]]
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[[Category: Lyase]]
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[[Category: Manganese]]
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[[Category: Metal-binding]]
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[[Category: Nucleotidyltransferase]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Polymerase]]
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[[Category: Scrunch site]]
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[[Category: Transferase]]
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[[Category: Transferase-dna complex]]
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[[Category: X-family]]
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Current revision

ternary complex of DNA polymerase lambda of a two nucleotide gapped DNA substrate with a C in the scrunch site

PDB ID 3hw8

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Proteopedia Page Contributors and Editors (what is this?)

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