1kjc
From Proteopedia
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{{Theoretical_model}} | {{Theoretical_model}} | ||
| - | [[ | + | ==THEORETICAL MODEL OF THE HUMAN CD6 LIGAND ALCAM (ACTIVATED LEUKOCYTE-CELL ADHESION MOLECULE), N-TERMINAL RECEPTOR- BINDING DOMAIN== |
| + | <StructureSection load='1kjc' size='340' side='right'caption='[[1kjc]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KJC FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kjc FirstGlance], [https://www.ebi.ac.uk/pdbsum/1kjc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kjc ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | CD6-ligand interactions have been implicated in the regulation of T-cell adhesion and activation. CD6 is a member of the scavenger receptor family, whereas its human ligand (ALCAM) belongs to the immunoglobulin superfamily. The extracellular region of ALCAM includes five immunoglobulin-like domains. As a fusion protein, the N-terminal extracellular domain of ALCAM (ALCAMD1) binds specifically to CD6. We report the construction, assessment, and analysis of a molecular model of ALCAMD1. The model defines the CDR-analogous loops, the location of N-linked glycosylation sites, and residues that form the beta-sheet faces of the immunoglobulin-like domain. Predicted structural characteristics of the A'GFCC'C" face of the model are consistent with the presence of monomeric and dimeric forms of ALCAMD1, which has implications for the receptor-ligand interactions. | ||
| - | + | Molecular model of the N-terminal receptor-binding domain of the human CD6 ligand ALCAM.,Bajorath J, Bowen MA, Aruffo A Protein Sci. 1995 Aug;4(8):1644-7. PMID:8520490<ref>PMID:8520490</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 1kjc" style="background-color:#fffaf0;"></div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Theoretical Model]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Aruffo, A]] | [[Category: Aruffo, A]] | ||
[[Category: Bajorath, J]] | [[Category: Bajorath, J]] | ||
[[Category: Bowen, M A]] | [[Category: Bowen, M A]] | ||
Current revision
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THEORETICAL MODEL OF THE HUMAN CD6 LIGAND ALCAM (ACTIVATED LEUKOCYTE-CELL ADHESION MOLECULE), N-TERMINAL RECEPTOR- BINDING DOMAIN
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