2fvb
From Proteopedia
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{{Theoretical_model}} | {{Theoretical_model}} | ||
| - | [[ | + | ==MODEL-BUILDING STUDY OF THE COMBINING SITES OF TWO ANTIBODIES TO ALPHA(1(RIGHT ARROW)6)DEXTRAN== |
| + | <StructureSection load='2fvb' size='340' side='right'caption='[[2fvb]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FVB FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fvb FirstGlance], [https://www.ebi.ac.uk/pdbsum/2fvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fvb ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Models of the Fv portion (containing the variable regions of the heavy and light chains) of two monoclonal anti-alpha (1----6)dextran antibodies, W3129 and 19.1.2, were constructed from amino acid sequences and the known three-dimensional structures of the Fv portions of McPC603 and J539. The modeled combining site of W3129 has a protrusion on one side, formed by the long complementarity-determining region 1 of the light chain and the long complementarity-determining region 3 of the heavy chain, and has a cavity accommodating a glucose moiety. The model of the 19.1.2 site is basically flat with a shallow groove that can accommodate several internal glucose units. These results support the earlier conclusions, from ligand binding data, that W3129 has a cavity-type site, involving the terminal nonreducing glucose residue (endbinder), whereas 19.1.2 has a groove-type site. | ||
| - | + | Model-building study of the combining sites of two antibodies to alpha (1----6)dextran.,Padlan EA, Kabat EA Proc Natl Acad Sci U S A. 1988 Sep;85(18):6885-9. PMID:2457920<ref>PMID:2457920</ref> | |
| - | = | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 2fvb" style="background-color:#fffaf0;"></div> | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Theoretical Model]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Kabat, E A]] | [[Category: Kabat, E A]] | ||
[[Category: Padlan, E A]] | [[Category: Padlan, E A]] | ||
Current revision
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MODEL-BUILDING STUDY OF THE COMBINING SITES OF TWO ANTIBODIES TO ALPHA(1(RIGHT ARROW)6)DEXTRAN
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