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1hlh

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{{Theoretical_model}}
{{Theoretical_model}}
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[[Image:1hlh.png|left|200px]]
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==PROPOSED STRUCTURE FOR THE DNA-BINDING DOMAIN OF THE HELIX- LOOP-HELIX FAMILY OF EUKARYOTIC GENE REGULATORY PROTEINS==
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<StructureSection load='1hlh' size='340' side='right'caption='[[1hlh]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HLH FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hlh FirstGlance], [https://www.ebi.ac.uk/pdbsum/1hlh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hlh ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A modelled tertiary structure for the dimeric HLH domain of the E47 protein is presented. Structural information was obtained from the aligned sequences of &gt; 40 members of the HLH family. The information was used to model each monomer as an alpha-helical hairpin, with knobs-into-holes packing of side-chains as found in antiparallel coiled-coil. The dimer forms a four-helix bundle with additional knobs-into-holes packing at the dimer interface. The size and electrostatic properties of core-forming residues are all accounted for in the model. The model does not violate any known properties of protein structure. The monomers are related by two-fold rotational symmetry, in agreement with the observed DNA-binding sites which are imperfect inverted repeats. The N-terminal basic region, in which DNA binding and base specificity reside, forms the first part of helix 1. A prediction based on the model structure is that the HLH domains do not bind to DNA in its B form but require a partially unwound conformation in order to enter the major groove.
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{{STRUCTURE_1hlh| PDB=1hlh | SCENE= }}
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Proposed structure for the DNA-binding domain of the helix-loop-helix family of eukaryotic gene regulatory proteins.,Gibson TJ, Thompson JD, Abagyan RA Protein Eng. 1993 Jan;6(1):41-50. PMID:8433970<ref>PMID:8433970</ref>
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===PROPOSED STRUCTURE FOR THE DNA-BINDING DOMAIN OF THE HELIX- LOOP-HELIX FAMILY OF EUKARYOTIC GENE REGULATORY PROTEINS===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_8433970}}
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<div class="pdbe-citations 1hlh" style="background-color:#fffaf0;"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:008433970</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Theoretical Model]]
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[[Category: Large Structures]]
[[Category: Abagyan, R A]]
[[Category: Abagyan, R A]]
[[Category: Gibson, T J]]
[[Category: Gibson, T J]]
[[Category: Thompson, J D]]
[[Category: Thompson, J D]]

Current revision

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

PROPOSED STRUCTURE FOR THE DNA-BINDING DOMAIN OF THE HELIX- LOOP-HELIX FAMILY OF EUKARYOTIC GENE REGULATORY PROTEINS

PDB ID 1hlh

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