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2hie

From Proteopedia

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{{Theoretical_model}}
{{Theoretical_model}}
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[[Image:2hie.png|left|200px]]
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==A HOMOLOGY MODEL OF HUMAN INTERFERON ALPHA-2==
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<StructureSection load='2hie' size='340' side='right'caption='[[2hie]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HIE FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hie FirstGlance], [https://www.ebi.ac.uk/pdbsum/2hie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hie ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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An atomic coordinate five alpha-helix three-dimensional model is presented for human interferon alpha-2 (HuIFN alpha 2). The HuIFN alpha 2 structure was constructed from murine interferon beta (MuIFN beta) by homology modeling using the STEREO and IMPACT programs. The HuIFN alpha 2 model is consistent with its known biochemical and biophysical properties including epitope mapping. Lysine residues predicted to be buried in the model were primarily unreactive with succinimidyl-7-amino-4-methylcoumarin-3-acetic acid (AMCA-NHS), a lysine modification agent, as shown by mass spectrometric analysis of tryptic digests. N-terminal sequence analysis of polypeptides generated by limited digestion of HuIFN alpha 2 with endoproteinase Lys-C demonstrated rapid cleavage at K31, which is consistent with the presence of this residue in a loop in the proposed HuIFN alpha 2 model. Based on this model structure potential receptor binding sites are identified.
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{{STRUCTURE_2hie| PDB=2hie | SCENE= }}
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A homology model of human interferon alpha-2.,Murgolo NJ, Windsor WT, Hruza A, Reichert P, Tsarbopoulos A, Baldwin S, Huang E, Pramanik B, Ealick S, Trotta PP Proteins. 1993 Sep;17(1):62-74. PMID:8234245<ref>PMID:8234245</ref>
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===A HOMOLOGY MODEL OF HUMAN INTERFERON ALPHA-2===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_8234245}}
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<div class="pdbe-citations 2hie" style="background-color:#fffaf0;"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:008234245</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Theoretical Model]]
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[[Category: Large Structures]]
[[Category: Ealick, S]]
[[Category: Ealick, S]]
[[Category: Hruza, A]]
[[Category: Hruza, A]]

Current revision

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

A HOMOLOGY MODEL OF HUMAN INTERFERON ALPHA-2

PDB ID 2hie

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