2kgr

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[[Image:2kgr.png|left|200px]]
 
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{{STRUCTURE_2kgr| PDB=2kgr | SCENE= }}
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==Solution structure of protein ITSN1 from Homo sapiens. Northeast Structural Genomics Consortium target HR5524A==
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<StructureSection load='2kgr' size='340' side='right'caption='[[2kgr]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2kgr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KGR FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kgr OCA], [https://pdbe.org/2kgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kgr RCSB], [https://www.ebi.ac.uk/pdbsum/2kgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kgr ProSAT], [https://www.topsan.org/Proteins/NESGC/2kgr TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/2kgr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kgr ConSurf].
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<div style="clear:both"></div>
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===Solution structure of protein ITSN1 from Homo sapiens. Northeast Structural Genomics Consortium target HR5524A===
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==See Also==
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*[[Intersectin|Intersectin]]
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== References ==
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==About this Structure==
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<references/>
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[[2kgr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGR OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Acton, T.]]
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[[Category: Large Structures]]
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[[Category: Ciccosanti, C.]]
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[[Category: Acton T]]
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[[Category: Everett, J.]]
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[[Category: Ciccosanti C]]
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[[Category: Ghosh, A.]]
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[[Category: Everett J]]
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[[Category: Hua, J.]]
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[[Category: Ghosh A]]
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[[Category: Jiang, M.]]
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[[Category: Hua J]]
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[[Category: Montelione, G.]]
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[[Category: Jiang M]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Montelione G]]
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[[Category: Shastry, R.]]
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[[Category: Shastry R]]
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[[Category: Swapna, G.]]
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[[Category: Swapna G]]
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[[Category: Szyperski, T.]]
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[[Category: Szyperski T]]
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[[Category: Wu, Y.]]
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[[Category: Wu Y]]
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[[Category: Xiao, R.]]
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[[Category: Xiao R]]
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[[Category: Zhang, Q.]]
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[[Category: Zhang Q]]
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[[Category: Cell junction]]
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[[Category: Cell projection]]
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[[Category: Endocytosis]]
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[[Category: Membrane]]
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[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Phosphoprotein]]
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[[Category: Protein binding]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Sh3 domain]]
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[[Category: Structural genomic]]
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[[Category: Synapse]]
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[[Category: Synaptosome]]
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Current revision

Solution structure of protein ITSN1 from Homo sapiens. Northeast Structural Genomics Consortium target HR5524A

PDB ID 2kgr

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