1aun

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[[Image:1aun.png|left|200px]]
 
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{{STRUCTURE_1aun| PDB=1aun | SCENE= }}
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==PATHOGENESIS-RELATED PROTEIN 5D FROM NICOTIANA TABACUM==
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<StructureSection load='1aun' size='340' side='right'caption='[[1aun]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1aun]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Nicotiana_tabacum Nicotiana tabacum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AUN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AUN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aun OCA], [https://pdbe.org/1aun PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aun RCSB], [https://www.ebi.ac.uk/pdbsum/1aun PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aun ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OLPA_TOBAC OLPA_TOBAC]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/au/1aun_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aun ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of tobacco PR-5d, an antifungal thaumatin-like protein isolated from cultured tobacco cells, was determined at the resolution of 1.8 A. The structure consists of 208 amino acid residues and 89 water molecules with a crystallographic R-factor of 0.169. The model has good stereochemistry, with respective root-mean-square deviations from the ideal values for bond and angle distances of 0.007 A and 1.542 degrees. Of the homologous PR-5 proteins, only those with antifungal activity had a common motif, a negatively charged surface cleft. This cleft is at the boundary between domains I and II, with a bottom part consisting of a three-stranded antiparallel beta-sheet in domain I. The acidic residues located in the hollow of the cleft form the beta-sheet region. Sequence and secondary structure analyses showed that the amino acid residues comprising the acidic cleft of PR-5d are conserved among other antifungal PR-5 proteins. This is the first report on the high-resolution crystal structure of an antifungal PR-5 protein. This structure provides insight into the function of pathogenesis-related proteins.
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===PATHOGENESIS-RELATED PROTEIN 5D FROM NICOTIANA TABACUM===
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Crystal structure of tobacco PR-5d protein at 1.8 A resolution reveals a conserved acidic cleft structure in antifungal thaumatin-like proteins.,Koiwa H, Kato H, Nakatsu T, Oda J, Yamada Y, Sato F J Mol Biol. 1999 Mar 5;286(4):1137-45. PMID:10047487<ref>PMID:10047487</ref>
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{{ABSTRACT_PUBMED_10047487}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1aun" style="background-color:#fffaf0;"></div>
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[[1aun]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Nicotiana_tabacum Nicotiana tabacum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AUN OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:010047487</ref><ref group="xtra">PMID:011917145</ref><ref group="xtra">PMID:014705035</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Nicotiana tabacum]]
[[Category: Nicotiana tabacum]]
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[[Category: Kato, H.]]
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[[Category: Kato H]]
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[[Category: Koiwa, H.]]
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[[Category: Koiwa H]]
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[[Category: Nakatsu, T.]]
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[[Category: Nakatsu T]]
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[[Category: Oda, J.]]
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[[Category: Oda J]]
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[[Category: Sato, F.]]
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[[Category: Sato F]]
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[[Category: Yamada, Y.]]
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[[Category: Yamada Y]]
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[[Category: Antifungal protein]]
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[[Category: Osmotin]]
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[[Category: Pathogenesis-related protein]]
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[[Category: Pr-5d]]
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[[Category: Thaumatin-like protein]]
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Current revision

PATHOGENESIS-RELATED PROTEIN 5D FROM NICOTIANA TABACUM

PDB ID 1aun

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