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1aq2

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[[Image:1aq2.gif|left|200px]]<br />
 
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<applet load="1aq2" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1aq2, resolution 1.9&Aring;" />
 
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'''PHOSPHOENOLPYRUVATE CARBOXYKINASE'''<br />
 
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==About this Structure==
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==PHOSPHOENOLPYRUVATE CARBOXYKINASE==
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1AQ2 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with MN, MG, ATP and PYR as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Phosphoenolpyruvate_carboxykinase_(ATP) Phosphoenolpyruvate carboxykinase (ATP)]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.49 4.1.1.49]]. Structure known Active Site: ACT. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AQ2 OCA]].
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<StructureSection load='1aq2' size='340' side='right'caption='[[1aq2]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1aq2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AQ2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aq2 OCA], [https://pdbe.org/1aq2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aq2 RCSB], [https://www.ebi.ac.uk/pdbsum/1aq2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aq2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PCKA_ECOLI PCKA_ECOLI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aq/1aq2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aq2 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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==See Also==
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Mg(2+)-Mn2+ clusters in enzyme-catalyzed phosphoryl-transfer reactions., Tari LW, Matte A, Goldie H, Delbaere LT, Nat Struct Biol. 1997 Dec;4(12):990-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9406547 9406547]
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*[[Phosphoenolpyruvate carboxykinase 3D structures|Phosphoenolpyruvate carboxykinase 3D structures]]
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[[Category: Escherichia coli]]
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__TOC__
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[[Category: Phosphoenolpyruvate carboxykinase (ATP)]]
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</StructureSection>
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[[Category: Single protein]]
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[[Category: Escherichia coli K-12]]
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[[Category: Delbaere, L.T.J.]]
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[[Category: Large Structures]]
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[[Category: Goldie, H.]]
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[[Category: Delbaere LTJ]]
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[[Category: Matte, A.]]
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[[Category: Goldie H]]
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[[Category: Tari, L.W.]]
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[[Category: Matte A]]
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[[Category: ATP]]
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[[Category: Tari LW]]
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[[Category: MG]]
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[[Category: MN]]
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[[Category: PYR]]
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[[Category: gluconeogenesis]]
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[[Category: kinase]]
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[[Category: lyase]]
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[[Category: nucleotide-triphosphate hydrolase]]
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[[Category: p-loop]]
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[[Category: protein-atp complex]]
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[[Category: transphosphorylating]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:50:42 2007''
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Current revision

PHOSPHOENOLPYRUVATE CARBOXYKINASE

PDB ID 1aq2

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