This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1a0f

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1a0f" [edit=sysop:move=sysop])
Current revision (06:26, 7 February 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1a0f.png|left|200px]]
 
-
{{STRUCTURE_1a0f| PDB=1a0f | SCENE= }}
+
==CRYSTAL STRUCTURE OF GLUTATHIONE S-TRANSFERASE FROM ESCHERICHIA COLI COMPLEXED WITH GLUTATHIONESULFONIC ACID==
 +
<StructureSection load='1a0f' size='340' side='right'caption='[[1a0f]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1a0f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A0F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A0F FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTS:GLUTATHIONE+SULFONIC+ACID'>GTS</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a0f OCA], [https://pdbe.org/1a0f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a0f RCSB], [https://www.ebi.ac.uk/pdbsum/1a0f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a0f ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/GSTA_ECOLI GSTA_ECOLI] Catalyzes the conjugation of reduced glutathione (GSH) to a wide number of exogenous and endogenous hydrophobic electrophiles. Shows activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and ethacrynic acid. Also possesses thiol:disulfide oxidoreductase activity, using GSH to reduce bis-(2-hydroxyethyl) disulfide (HEDS). Has a low level of glutathione-dependent peroxidase activity toward cumene hydroperoxide. Is important for defense against oxidative stress, probably via its peroxidase activity.<ref>PMID:7798255</ref> <ref>PMID:2185038</ref> <ref>PMID:17018556</ref> <ref>PMID:18778244</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a0/1a0f_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a0f ConSurf].
 +
<div style="clear:both"></div>
-
===CRYSTAL STRUCTURE OF GLUTATHIONE S-TRANSFERASE FROM ESCHERICHIA COLI COMPLEXED WITH GLUTATHIONESULFONIC ACID===
+
==See Also==
-
 
+
*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
-
{{ABSTRACT_PUBMED_9680481}}
+
== References ==
-
 
+
<references/>
-
==About this Structure==
+
__TOC__
-
[[1a0f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A0F OCA].
+
</StructureSection>
-
 
+
[[Category: Escherichia coli K-12]]
-
==Reference==
+
[[Category: Large Structures]]
-
<ref group="xtra">PMID:009680481</ref><references group="xtra"/>
+
[[Category: Harada S]]
-
[[Category: Escherichia coli k-12]]
+
[[Category: Inoue H]]
-
[[Category: Glutathione transferase]]
+
[[Category: Nishida M]]
-
[[Category: Harada, S.]]
+
[[Category: Noguchi S]]
-
[[Category: Inoue, H.]]
+
[[Category: Satow Y]]
-
[[Category: Nishida, M.]]
+
[[Category: Takahashi K]]
-
[[Category: Noguchi, S.]]
+
-
[[Category: Satow, Y.]]
+
-
[[Category: Takahashi, K.]]
+
-
[[Category: Detoxification]]
+
-
[[Category: Glutahione conjugation]]
+
-
[[Category: Transferase]]
+

Current revision

CRYSTAL STRUCTURE OF GLUTATHIONE S-TRANSFERASE FROM ESCHERICHIA COLI COMPLEXED WITH GLUTATHIONESULFONIC ACID

PDB ID 1a0f

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1a0f"
Personal tools