1agq

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (23:47, 20 November 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1agq.png|left|200px]]
 
-
{{STRUCTURE_1agq| PDB=1agq | SCENE= }}
+
==GLIAL CELL-DERIVED NEUROTROPHIC FACTOR FROM RAT==
 +
<StructureSection load='1agq' size='340' side='right'caption='[[1agq]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1agq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AGQ FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1agq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1agq OCA], [https://pdbe.org/1agq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1agq RCSB], [https://www.ebi.ac.uk/pdbsum/1agq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1agq ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/GDNF_RAT GDNF_RAT] Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. May also modulate local neuronal effects in distal regions of the motor neuron.<ref>PMID:10828539</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ag/1agq_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1agq ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The crystal structure of glial cell-derived neurotrophic factor (GDNF) reveals two independent copies of the dimer that differ significantly through a hinge bending at the central, disulphide-rich region. GDNF is compared with other members of the TGF-beta family, and potential receptor binding surfaces are identified.
-
===GLIAL CELL-DERIVED NEUROTROPHIC FACTOR FROM RAT===
+
X-ray structure of glial cell-derived neurotrophic factor at 1.9 A resolution and implications for receptor binding.,Eigenbrot C, Gerber N Nat Struct Biol. 1997 Jun;4(6):435-8. PMID:9187648<ref>PMID:9187648</ref>
-
{{ABSTRACT_PUBMED_9187648}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
==About this Structure==
+
<div class="pdbe-citations 1agq" style="background-color:#fffaf0;"></div>
-
[[1agq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AGQ OCA].
+
== References ==
-
 
+
<references/>
-
==Reference==
+
__TOC__
-
<ref group="xtra">PMID:009187648</ref><references group="xtra"/>
+
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
-
[[Category: Eigenbrot, C.]]
+
[[Category: Eigenbrot C]]
-
[[Category: Gerber, N.]]
+
[[Category: Gerber N]]
-
[[Category: Cystine knot]]
+
-
[[Category: Growth factor]]
+
-
[[Category: Neurotrophic factor]]
+

Current revision

GLIAL CELL-DERIVED NEUROTROPHIC FACTOR FROM RAT

PDB ID 1agq

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1agq"
Personal tools