1a6y

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:48, 2 August 2023) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1a6y.png|left|200px]]
 
-
{{STRUCTURE_1a6y| PDB=1a6y | SCENE= }}
+
==REVERBA ORPHAN NUCLEAR RECEPTOR/DNA COMPLEX==
 +
<StructureSection load='1a6y' size='340' side='right'caption='[[1a6y]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1a6y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A6Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A6Y FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5IU:5-IODO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>5IU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a6y OCA], [https://pdbe.org/1a6y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a6y RCSB], [https://www.ebi.ac.uk/pdbsum/1a6y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a6y ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/NR1D1_HUMAN NR1D1_HUMAN] Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1 transcription (By similarity). Possible receptor for triiodothyronine.<ref>PMID:2539258</ref> <ref>PMID:1971514</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a6/1a6y_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a6y ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The nuclear hormone receptors form the largest known family of transcription factors. The current notion of receptor DNA discrimination, based solely on one major type of hexameric half-site and a highly conserved 66-residue core DNA-binding domain (DBD), does not adequately describe how more than 150 nonsteroid receptors differentiate among response elements. Here, we describe the 2.3 A crystal structure of the DNA-binding region of the orphan receptor RevErb arranged as a tandem homodimer on its optimal response element. The structure reveals the presence of a second major protein-DNA interface adjacent to the classical one involving the half-sites. A sequence comparison of orphan receptors suggests that unique minor-groove interactions involving the receptor hinge regions impart the necessary DNA and dimerization specificity.
-
===REVERBA ORPHAN NUCLEAR RECEPTOR/DNA COMPLEX===
+
Structural elements of an orphan nuclear receptor-DNA complex.,Zhao Q, Khorasanizadeh S, Miyoshi Y, Lazar MA, Rastinejad F Mol Cell. 1998 May;1(6):849-61. PMID:9660968<ref>PMID:9660968</ref>
-
{{ABSTRACT_PUBMED_9660968}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
==About this Structure==
+
<div class="pdbe-citations 1a6y" style="background-color:#fffaf0;"></div>
-
[[1a6y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A6Y OCA].
+
== References ==
-
 
+
<references/>
-
==Reference==
+
__TOC__
-
<ref group="xtra">PMID:009660968</ref><ref group="xtra">PMID:014702633</ref><ref group="xtra">PMID:015048824</ref><references group="xtra"/>
+
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Khorasanizadeh, S.]]
+
[[Category: Large Structures]]
-
[[Category: Rastinejad, F.]]
+
[[Category: Khorasanizadeh S]]
-
[[Category: Zhao, Q.]]
+
[[Category: Rastinejad F]]
-
[[Category: Dna-binding]]
+
[[Category: Zhao Q]]
-
[[Category: Nuclear receptor]]
+
-
[[Category: Orphan receptor]]
+
-
[[Category: Rev-erb]]
+
-
[[Category: Reverb]]
+
-
[[Category: Transcription regulation]]
+
-
[[Category: Transcription-dna complex]]
+

Current revision

REVERBA ORPHAN NUCLEAR RECEPTOR/DNA COMPLEX

PDB ID 1a6y

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1a6y"
Personal tools