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1an4
From Proteopedia
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| - | [[Image:1an4.png|left|200px]] | ||
| - | + | ==STRUCTURE AND FUNCTION OF THE B/HLH/Z DOMAIN OF USF== | |
| - | + | <StructureSection load='1an4' size='340' side='right'caption='[[1an4]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1an4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AN4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AN4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1an4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1an4 OCA], [https://pdbe.org/1an4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1an4 RCSB], [https://www.ebi.ac.uk/pdbsum/1an4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1an4 ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[1an4]] is a 4 chain structure with sequence from [ | + | == Disease == |
| - | + | [https://www.uniprot.org/uniprot/USF1_HUMAN USF1_HUMAN] Genetic variations in USF1 are associated with hyperlipidemia combined type 1 (HYPLIP1) [MIM:[https://omim.org/entry/602491 602491]; also known as familial combined hyperlipidemia type 1 (FCHL1). HYPLIP1 is characterized by elevated levels of serum total cholesterol, triglycerides or both, and is observed in about 20% of individuals with premature coronary heart disease.<ref>PMID:14991056</ref> | |
| - | == | + | == Function == |
| - | < | + | [https://www.uniprot.org/uniprot/USF1_HUMAN USF1_HUMAN] Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. |
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/an/1an4_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1an4 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Burley | + | [[Category: Burley SK]] |
| - | [[Category: | + | [[Category: Ferre-D'Amare AR]] |
| - | [[Category: | + | [[Category: Pognonec P]] |
| - | [[Category: | + | [[Category: Roeder RG]] |
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Current revision
STRUCTURE AND FUNCTION OF THE B/HLH/Z DOMAIN OF USF
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