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1aqx

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[[Image:1aqx.png|left|200px]]
 
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{{STRUCTURE_1aqx| PDB=1aqx | SCENE= }}
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==GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH MEISENHEIMER COMPLEX==
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<StructureSection load='1aqx' size='340' side='right'caption='[[1aqx]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1aqx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AQX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTD:1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE'>GTD</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aqx OCA], [https://pdbe.org/1aqx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aqx RCSB], [https://www.ebi.ac.uk/pdbsum/1aqx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aqx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.<ref>PMID:21668448</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aq/1aqx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aqx ConSurf].
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<div style="clear:both"></div>
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===GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH MEISENHEIMER COMPLEX===
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==See Also==
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*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
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{{ABSTRACT_PUBMED_9351803}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1aqx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQX OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:009351803</ref><references group="xtra"/>
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[[Category: Glutathione transferase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Fahl, W E.]]
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[[Category: Large Structures]]
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[[Category: Huber, R.]]
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[[Category: Fahl WE]]
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[[Category: Manoharan, T H.]]
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[[Category: Huber R]]
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[[Category: Prade, L.]]
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[[Category: Manoharan TH]]
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[[Category: Reuter, W.]]
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[[Category: Prade L]]
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[[Category: Class pi]]
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[[Category: Reuter W]]
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[[Category: Glutathione s-transferase]]
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[[Category: Transferase]]
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[[Category: Transferase-substrate complex]]
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[[Category: Transition state]]
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Current revision

GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH MEISENHEIMER COMPLEX

PDB ID 1aqx

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