This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1aho
From Proteopedia
(Difference between revisions)
| (8 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:1aho.png|left|200px]] | ||
| - | + | ==THE AB INITIO STRUCTURE DETERMINATION AND REFINEMENT OF A SCORPION PROTEIN TOXIN== | |
| - | + | <StructureSection load='1aho' size='340' side='right'caption='[[1aho]], [[Resolution|resolution]] 0.96Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1aho]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Androctonus_australis_hector Androctonus australis hector]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AHO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AHO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.96Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aho OCA], [https://pdbe.org/1aho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aho RCSB], [https://www.ebi.ac.uk/pdbsum/1aho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aho ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[1aho]] is a 1 chain structure with sequence from [ | + | == Function == |
| - | + | [https://www.uniprot.org/uniprot/SCX2_ANDAU SCX2_ANDAU] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin is active against mammals. | |
| - | + | == Evolutionary Conservation == | |
| - | < | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [[ | + | Check<jmol> |
| - | [[ | + | <jmolCheckbox> |
| - | [[ | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ah/1aho_consurf.spt"</scriptWhenChecked> |
| - | [[Category: | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | [[Category: | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | [[Category: | + | </jmolCheckbox> |
| - | [[Category: | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aho ConSurf]. |
| - | [[Category: | + | <div style="clear:both"></div> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Androctonus australis hector]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Blessing RH]] |
| + | [[Category: Ealick SE]] | ||
| + | [[Category: Fontecilla-Camps JC]] | ||
| + | [[Category: Hauptman HA]] | ||
| + | [[Category: Housset D]] | ||
| + | [[Category: Langs DA]] | ||
| + | [[Category: Miller R]] | ||
| + | [[Category: Smith GD]] | ||
Current revision
THE AB INITIO STRUCTURE DETERMINATION AND REFINEMENT OF A SCORPION PROTEIN TOXIN
| |||||||||||
