1biv
From Proteopedia
(Difference between revisions)
m (Protected "1biv" [edit=sysop:move=sysop]) |
|||
| (9 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:1biv.png|left|200px]] | ||
| - | + | ==BOVINE IMMUNODEFICIENCY VIRUS TAT-TAR COMPLEX, NMR, 5 STRUCTURES== | |
| - | + | <StructureSection load='1biv' size='340' side='right'caption='[[1biv]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1biv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovine_immunodeficiency_virus Bovine immunodeficiency virus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BIV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1biv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1biv OCA], [https://pdbe.org/1biv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1biv RCSB], [https://www.ebi.ac.uk/pdbsum/1biv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1biv ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[1biv]] is a 2 chain structure with sequence from [ | + | == Function == |
| - | [[ | + | [https://www.uniprot.org/uniprot/TAT_BIV29 TAT_BIV29] Nuclear transcriptional activator of viral gene expression, that is essential for viral transcription from the LTR promoter and replication. Acts as a sequence-specific molecular adapter, directing components of the cellular transcription machinery to the viral RNA to promote processive transcription elongation by the RNA polymerase II (RNA pol II) complex, thereby increasing the level of full-length transcripts. Tat binds to a hairpin structure at the 5'-end of all nascent viral mRNAs referred to as the transactivation responsive RNA element (TAR RNA) in a CCNT1-independent mode. Tat then recruits the CCNT1/cyclin-T1 component of the P-TEFb complex (CDK9 and CCNT1), which promotes RNA chain elongation. The CDK9 component of P-TEFb hyperphosphorylates the C-terminus of RNA Pol II that becomes stabilized and much more processive (Probable).<ref>PMID:10846086</ref> |
| - | [ | + | == References == |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | [ | + | </StructureSection> |
[[Category: Bovine immunodeficiency virus]] | [[Category: Bovine immunodeficiency virus]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Synthetic construct]] |
| - | [[Category: | + | [[Category: Kumar RA]] |
| - | [[Category: | + | [[Category: Patel DJ]] |
| - | [[Category: | + | [[Category: Ye X]] |
Current revision
BOVINE IMMUNODEFICIENCY VIRUS TAT-TAR COMPLEX, NMR, 5 STRUCTURES
| |||||||||||
