1ot0

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[[Image:1ot0.jpg|left|200px]]<br /><applet load="1ot0" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1ot0" />
 
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'''Structure of Antimicrobial Peptide, HP (2-20) and its Analogues Derived from Helicobacter pylori, as Determined by 1H NMR Spectroscopy'''<br />
 
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==About this Structure==
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==Structure of Antimicrobial Peptide, HP (2-20) and its Analogues Derived from Helicobacter pylori, as Determined by 1H NMR Spectroscopy==
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1OT0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori] with <scene name='pdbligand=NH2:'>NH2</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OT0 OCA].
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<StructureSection load='1ot0' size='340' side='right'caption='[[1ot0]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ot0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OT0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ot0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ot0 OCA], [https://pdbe.org/1ot0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ot0 RCSB], [https://www.ebi.ac.uk/pdbsum/1ot0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ot0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RL1_HELPY RL1_HELPY] Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity).[HAMAP-Rule:MF_01318] Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA (By similarity).[HAMAP-Rule:MF_01318] Peptides originating from the N-terminal end of L1 have antibacterial activity against bacteria such as E.coli and B.megaterium and modest antifungal activities. Has no effect on H.pylori itself. Peptides are not hemolytic against mammalian cells. These peptides may be released in the stomach during altruistic lysis to kill other fast growing bacteria.[HAMAP-Rule:MF_01318]
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__TOC__
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</StructureSection>
[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Hahm, K S.]]
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[[Category: Hahm K-S]]
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[[Category: Kim, Y.]]
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[[Category: Kim Y]]
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[[Category: Lee, D G.]]
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[[Category: Lee DG]]
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[[Category: Lee, K H.]]
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[[Category: Lee KH]]
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[[Category: Park, Y.]]
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[[Category: Park Y]]
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[[Category: NH2]]
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[[Category: antibiotic]]
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[[Category: coil-helix-coil]]
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[[Category: ribosomal protein]]
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[[Category: rrna-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:21:14 2008''
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Current revision

Structure of Antimicrobial Peptide, HP (2-20) and its Analogues Derived from Helicobacter pylori, as Determined by 1H NMR Spectroscopy

PDB ID 1ot0

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