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| - | [[Image:1otz.gif|left|200px]]<br /><applet load="1otz" size="350" color="white" frame="true" align="right" spinBox="true" | + | #REDIRECT [[4v46]] This PDB entry is obsolete and replaced by 4v46 |
| - | caption="1otz, resolution 3.3Å" />
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| - | '''Crystal structure of the BAFF-BAFF-R complex (part I)'''<br />
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| - | ==Overview==
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| - | B-cell activating factor (BAFF) is a key regulator of B-lymphocyte development. Its biological role is mediated by the specific receptors BCMA, TACI and BAFF-R. We have determined the crystal structure of the extracellular domain of BAFF-R bound to BAFF at a resolution of 3.3 A. The cysteine-rich domain (CRD) of the BAFF-R extracellular domain adopts a beta-hairpin structure and binds to the virus-like BAFF cage in a 1:1 molar ratio. The conserved DxL motif of BAFF-R is located on the tip of the beta-turn and is indispensable in the binding of BAFF. The crystal structure shows that a unique dimeric contact occurs between the BAFF-R monomers in the virus-like cage complex. The extracellular domain of TACI contains two CRDs, both of which contain the DxL motif. Modeling of TACI-BAFF complex suggests that both CDRs simultaneously interact with the BAFF dimer in the virus-like cage.
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| - | ==About this Structure==
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| - | 1OTZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OTZ OCA].
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| - | ==Reference==
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| - | Crystal structure of the BAFF-BAFF-R complex and its implications for receptor activation., Kim HM, Yu KS, Lee ME, Shin DR, Kim YS, Paik SG, Yoo OJ, Lee H, Lee JO, Nat Struct Biol. 2003 May;10(5):342-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12715002 12715002]
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| - | [[Category: Homo sapiens]]
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| - | [[Category: Single protein]]
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| - | [[Category: MG]]
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| - | [[Category: cytokine]]
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:21:32 2008''
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Current revision
- REDIRECT 4v46 This PDB entry is obsolete and replaced by 4v46
