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1bj8

From Proteopedia

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[[Image:1bj8.png|left|200px]]
 
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{{STRUCTURE_1bj8| PDB=1bj8 | SCENE= }}
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==THIRD N-TERMINAL DOMAIN OF GP130, NMR, MINIMIZED AVERAGE STRUCTURE==
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<StructureSection load='1bj8' size='340' side='right'caption='[[1bj8]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1bj8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BJ8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bj8 OCA], [https://pdbe.org/1bj8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bj8 RCSB], [https://www.ebi.ac.uk/pdbsum/1bj8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bj8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IL6RB_HUMAN IL6RB_HUMAN] Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bj/1bj8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bj8 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The transmembrane glycoprotein gp130 is the common signal transducing receptor subunit of the interleukin-6-type cytokines. It is a member of the cytokine-receptor superfamily predicted to consist of six domains in its extracellular part. The second and third domain constitute the cytokine-binding module defined by a set of four conserved cysteines and a WSXWS motif, respectively. The three-dimensional structure of the carboxy-terminal domain of this region was determined by multidimensional NMR. The domain consists of seven beta-strands constituting a fibronectin type III-like topology. The structure reveals that the WSDWS motif of gp130 is part of an extended tryptophan/arginine zipper which modulates the conformation of the CD loop.
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===THIRD N-TERMINAL DOMAIN OF GP130, NMR, MINIMIZED AVERAGE STRUCTURE===
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The signal transducer gp130: solution structure of the carboxy-terminal domain of the cytokine receptor homology region.,Kernebeck T, Pflanz S, Muller-Newen G, Kurapkat G, Scheek RM, Dijkstra K, Heinrich PC, Wollmer A, Grzesiek S, Grotzinger J Protein Sci. 1999 Jan;8(1):5-12. PMID:10210178<ref>PMID:10210178</ref>
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{{ABSTRACT_PUBMED_10210178}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1bj8" style="background-color:#fffaf0;"></div>
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[[1bj8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJ8 OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:010210178</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Dijkstra, K.]]
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[[Category: Large Structures]]
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[[Category: Grotzinger, J.]]
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[[Category: Dijkstra K]]
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[[Category: Grzesiek, S.]]
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[[Category: Grotzinger J]]
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[[Category: Heinrich, P C.]]
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[[Category: Grzesiek S]]
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[[Category: Kernebeck, T.]]
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[[Category: Heinrich PC]]
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[[Category: Kurapkat, G.]]
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[[Category: Kernebeck T]]
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[[Category: Muller-Newen, G.]]
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[[Category: Kurapkat G]]
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[[Category: Pflanz, S.]]
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[[Category: Muller-Newen G]]
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[[Category: Scheek, R M.]]
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[[Category: Pflanz S]]
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[[Category: Wollmer, A.]]
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[[Category: Scheek RM]]
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[[Category: Glycoprotein]]
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[[Category: Wollmer A]]
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[[Category: Receptor]]
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[[Category: Signal transducer of il-6 type cytokine]]
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[[Category: Third n-terminal domain]]
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[[Category: Transmembrane]]
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Current revision

THIRD N-TERMINAL DOMAIN OF GP130, NMR, MINIMIZED AVERAGE STRUCTURE

PDB ID 1bj8

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