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1ovz

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[[Image:1ovz.jpg|left|200px]]<br /><applet load="1ovz" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1ovz, resolution 3.00&Aring;" />
 
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'''Crystal structure of human FcaRI'''<br />
 
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==Overview==
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==Crystal structure of human FcaRI==
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Immunoglobulin-alpha (IgA)-bound antigens induce immune effector responses by activating the IgA-specific receptor FcalphaRI (CD89) on immune cells. Here we present crystal structures of human FcalphaRI alone and in a complex with the Fc region of IgA1 (Fcalpha). FcalphaRI has two immunoglobulin-like domains that are oriented at approximately right angles to each other. Fcalpha resembles the Fcs of immunoglobulins IgG and IgE, but has differently located interchain disulphide bonds and external rather than interdomain N-linked carbohydrates. Unlike 1:1 FcgammaRIII:IgG and Fc epsilon RI:IgE complexes, two FcalphaRI molecules bind each Fcalpha dimer, one at each Calpha2-Calpha3 junction. The FcalphaRI-binding site on IgA1 overlaps the reported polymeric immunoglobulin receptor (pIgR)-binding site, which might explain why secretory IgA cannot initiate phagocytosis or bind to FcalphaRI-expressing cells in the absence of an integrin co-receptor.
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<StructureSection load='1ovz' size='340' side='right'caption='[[1ovz]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1ovz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OVZ FirstGlance]. <br>
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1OVZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=TRS:'>TRS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OVZ OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ovz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ovz OCA], [https://pdbe.org/1ovz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ovz RCSB], [https://www.ebi.ac.uk/pdbsum/1ovz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ovz ProSAT]</span></td></tr>
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Insights into IgA-mediated immune responses from the crystal structures of human FcalphaRI and its complex with IgA1-Fc., Herr AB, Ballister ER, Bjorkman PJ, Nature. 2003 Jun 5;423(6940):614-20. Epub 2003 May 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12768205 12768205]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FCAR_HUMAN FCAR_HUMAN] Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ov/1ovz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ovz ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ballister, E R.]]
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[[Category: Ballister ER]]
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[[Category: Bjorkman, P J.]]
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[[Category: Bjorkman PJ]]
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[[Category: Herr, A B.]]
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[[Category: Herr AB]]
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[[Category: NAG]]
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[[Category: TRS]]
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[[Category: cd89]]
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[[Category: fc receptor]]
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[[Category: fcari]]
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[[Category: iga]]
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[[Category: immunoglobulin-like domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:22:14 2008''
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Current revision

Crystal structure of human FcaRI

PDB ID 1ovz

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