1dhm

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[[Image:1dhm.png|left|200px]]
 
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{{STRUCTURE_1dhm| PDB=1dhm | SCENE= }}
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==DNA-BINDING DOMAIN OF E2 FROM HUMAN PAPILLOMAVIRUS-31, NMR, MINIMIZED AVERAGE STRUCTURE==
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<StructureSection load='1dhm' size='340' side='right'caption='[[1dhm]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1dhm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_31 Human papillomavirus 31]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DHM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DHM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dhm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dhm OCA], [https://pdbe.org/1dhm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dhm RCSB], [https://www.ebi.ac.uk/pdbsum/1dhm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dhm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VE2_HPV31 VE2_HPV31] E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dh/1dhm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dhm ConSurf].
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<div style="clear:both"></div>
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===DNA-BINDING DOMAIN OF E2 FROM HUMAN PAPILLOMAVIRUS-31, NMR, MINIMIZED AVERAGE STRUCTURE===
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==See Also==
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*[[Regulatory protein E2|Regulatory protein E2]]
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{{ABSTRACT_PUBMED_8652551}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Human papillomavirus 31]]
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[[1dhm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_31 Human papillomavirus type 31]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DHM OCA].
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[[Category: Large Structures]]
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[[Category: Egan DA]]
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==Reference==
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[[Category: Fesik SW]]
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<ref group="xtra">PMID:008652551</ref><ref group="xtra">PMID:011734033</ref><references group="xtra"/>
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[[Category: Holzman TF]]
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[[Category: Human papillomavirus type 31]]
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[[Category: Liang H]]
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[[Category: Egan, D A.]]
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[[Category: Meadows RP]]
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[[Category: Fesik, S W.]]
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[[Category: Petros AP]]
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[[Category: Holzman, T F.]]
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[[Category: Robins T]]
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[[Category: Liang, H.]]
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[[Category: Walter K]]
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[[Category: Meadows, R P.]]
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[[Category: Yoon HS]]
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[[Category: Petros, A P.]]
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[[Category: Robins, T.]]
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[[Category: Walter, K.]]
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[[Category: Yoon, H S.]]
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[[Category: Dna-binding protein]]
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[[Category: Early protein]]
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[[Category: Trans-acting factor]]
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[[Category: Transcriptional activator]]
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Current revision

DNA-BINDING DOMAIN OF E2 FROM HUMAN PAPILLOMAVIRUS-31, NMR, MINIMIZED AVERAGE STRUCTURE

PDB ID 1dhm

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