1d2d

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[[Image:1d2d.png|left|200px]]
 
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{{STRUCTURE_1d2d| PDB=1d2d | SCENE= }}
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==Hamster EprS second repeated element. NMR, 5 structures==
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<StructureSection load='1d2d' size='340' side='right'caption='[[1d2d]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1d2d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D2D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D2D FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d2d OCA], [https://pdbe.org/1d2d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d2d RCSB], [https://www.ebi.ac.uk/pdbsum/1d2d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d2d ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SYEP_CRIGR SYEP_CRIGR]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d2/1d2d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1d2d ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Aminoacyl-tRNA synthetases of higher eukaryotes possess polypeptide extensions in contrast to their prokaryotic counterparts. These extra domains of poorly understood function are believed to be involved in protein-protein or protein-RNA interactions. Here we showed by gel retardation and filter binding experiments that the repeated units that build the linker region of the bifunctional glutamyl-prolyl-tRNA synthetase had a general RNA-binding capacity. The solution structure of one of these repeated motifs was also solved by NMR spectroscopy. One repeat is built around an antiparallel coiled-coil. Strikingly, the conserved lysine and arginine residues form a basic patch on one side of the structure, presenting a suitable docking surface for nucleic acids. Therefore, this repeated motif may represent a novel type of general RNA-binding domain appended to eukaryotic aminoacyl-tRNA synthetases to serve as a cis-acting tRNA-binding cofactor.
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===Hamster EprS second repeated element. NMR, 5 structures===
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A recurrent RNA-binding domain is appended to eukaryotic aminoacyl-tRNA synthetases.,Cahuzac B, Berthonneau E, Birlirakis N, Guittet E, Mirande M EMBO J. 2000 Feb 1;19(3):445-52. PMID:10654942<ref>PMID:10654942</ref>
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{{ABSTRACT_PUBMED_10654942}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1d2d" style="background-color:#fffaf0;"></div>
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[[1d2d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D2D OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:010654942</ref><references group="xtra"/>
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</StructureSection>
[[Category: Cricetulus griseus]]
[[Category: Cricetulus griseus]]
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[[Category: Berthonneau, E.]]
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[[Category: Large Structures]]
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[[Category: Birlirakis, N.]]
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[[Category: Berthonneau E]]
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[[Category: Cahuzac, B.]]
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[[Category: Birlirakis N]]
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[[Category: Guittet, E.]]
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[[Category: Cahuzac B]]
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[[Category: Mirande, M.]]
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[[Category: Guittet E]]
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[[Category: Ligase]]
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[[Category: Mirande M]]
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[[Category: Protein transcription]]
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Current revision

Hamster EprS second repeated element. NMR, 5 structures

PDB ID 1d2d

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