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1dfc

From Proteopedia

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[[Image:1dfc.png|left|200px]]
 
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{{STRUCTURE_1dfc| PDB=1dfc | SCENE= }}
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==CRYSTAL STRUCTURE OF HUMAN FASCIN, AN ACTIN-CROSSLINKING PROTEIN==
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<StructureSection load='1dfc' size='340' side='right'caption='[[1dfc]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1dfc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DFC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dfc OCA], [https://pdbe.org/1dfc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dfc RCSB], [https://www.ebi.ac.uk/pdbsum/1dfc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dfc ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1dfc TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FSCN1_HUMAN FSCN1_HUMAN] Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.<ref>PMID:9362073</ref> <ref>PMID:9571235</ref> <ref>PMID:20137952</ref> <ref>PMID:20393565</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/df/1dfc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dfc ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF HUMAN FASCIN, AN ACTIN-CROSSLINKING PROTEIN===
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==See Also==
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*[[Fascin|Fascin]]
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{{ABSTRACT_PUBMED_20434460}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1dfc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DFC OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:020434460</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Almo, S C.]]
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[[Category: Large Structures]]
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[[Category: Burley, S K.]]
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[[Category: Almo SC]]
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[[Category: Fedorov, A A.]]
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[[Category: Burley SK]]
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[[Category: Fedorov, E V.]]
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[[Category: Fedorov AA]]
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[[Category: Matsumura, F.]]
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[[Category: Fedorov EV]]
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[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics.]]
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[[Category: Matsumura F]]
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[[Category: Ono, S.]]
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[[Category: Ono S]]
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[[Category: Beta-trefoil fold for all four domain]]
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[[Category: New york sgx research center for structural genomic]]
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[[Category: Nysgxrc]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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[[Category: Structural protein]]
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Current revision

CRYSTAL STRUCTURE OF HUMAN FASCIN, AN ACTIN-CROSSLINKING PROTEIN

PDB ID 1dfc

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