1ddv

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[[Image:1ddv.png|left|200px]]
 
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{{STRUCTURE_1ddv| PDB=1ddv | SCENE= }}
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==CRYSTAL STRUCTURE OF THE HOMER EVH1 DOMAIN WITH BOUND MGLUR PEPTIDE==
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<StructureSection load='1ddv' size='340' side='right'caption='[[1ddv]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF THE HOMER EVH1 DOMAIN WITH BOUND MGLUR PEPTIDE===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ddv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DDV FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10798399}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ddv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ddv OCA], [https://pdbe.org/1ddv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ddv RCSB], [https://www.ebi.ac.uk/pdbsum/1ddv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ddv ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1ddv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDV OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/HOME1_RAT HOME1_RAT] Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Differentially regulates the functions of the calcium activated channel ryanodine receptors RYR1 and RYR2. Isoform 1 decreases the activity of RYR2, and increases the activity of RYR1, whereas isoform 3 counteracts the effects by competing for binding sites. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1, and isoform 2 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.<ref>PMID:14528310</ref>
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==Reference==
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== Evolutionary Conservation ==
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<ref group="xtra">PMID:010798399</ref><references group="xtra"/>
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dd/1ddv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ddv ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Beneken, J.]]
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[[Category: Beneken J]]
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[[Category: Leahy, D J.]]
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[[Category: Leahy DJ]]
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[[Category: Tu, J C.]]
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[[Category: Tu JC]]
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[[Category: Worley, P F.]]
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[[Category: Worley PF]]
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[[Category: Xiao, B.]]
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[[Category: Xiao B]]
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[[Category: Beta turn]]
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[[Category: Polyproline recognition]]
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[[Category: Protein-ligand complex]]
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[[Category: Signaling protein]]
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Current revision

CRYSTAL STRUCTURE OF THE HOMER EVH1 DOMAIN WITH BOUND MGLUR PEPTIDE

PDB ID 1ddv

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