1cqx

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[[Image:1cqx.png|left|200px]]
 
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{{STRUCTURE_1cqx| PDB=1cqx | SCENE= }}
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==Crystal structure of the flavohemoglobin from Alcaligenes eutrophus at 1.75 A resolution==
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<StructureSection load='1cqx' size='340' side='right'caption='[[1cqx]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1cqx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cupriavidus_necator Cupriavidus necator]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CQX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CQX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DGG:1-[GLYCEROLYLPHOSPHONYL]-2-[8-(2-HEXYL-CYCLOPROPYL)-OCTANAL-1-YL]-3-[HEXADECANAL-1-YL]-GLYCEROL'>DGG</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cqx OCA], [https://pdbe.org/1cqx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cqx RCSB], [https://www.ebi.ac.uk/pdbsum/1cqx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cqx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HMP_CUPNH HMP_CUPNH] Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress. In the presence of oxygen and NADH, FHP has NADH oxidase activity, which leads to the generation of superoxide and H(2)O(2), both in vitro and in vivo, and it has been suggested that FHP might act as an amplifier of superoxide stress. Under anaerobic conditions, FHP also exhibits nitric oxide reductase and FAD reductase activities. However, all these reactions are much lower than NOD activity.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cq/1cqx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cqx ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the flavohemoglobin from Alcaligenes eutrophus at 1.75 A resolution===
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==See Also==
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*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
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{{ABSTRACT_PUBMED_8557026}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[1cqx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cupriavidus_necator Cupriavidus necator]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CQX OCA].
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==Reference==
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<ref group="xtra">PMID:008557026</ref><references group="xtra"/>
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[[Category: Cupriavidus necator]]
[[Category: Cupriavidus necator]]
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[[Category: Cramm, R.]]
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[[Category: Large Structures]]
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[[Category: Ermler, U.]]
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[[Category: Cramm R]]
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[[Category: Friedrich, B.]]
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[[Category: Ermler U]]
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[[Category: Siddiqui, R A.]]
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[[Category: Friedrich B]]
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[[Category: Globin fold]]
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[[Category: Siddiqui RA]]
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[[Category: Helix-flanked five-stranded parallel beta sheet]]
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[[Category: Lipid binding protein]]
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[[Category: Six-stranded antiparallel beta sheet]]
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Current revision

Crystal structure of the flavohemoglobin from Alcaligenes eutrophus at 1.75 A resolution

PDB ID 1cqx

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