1ctl

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[[Image:1ctl.png|left|200px]]
 
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{{STRUCTURE_1ctl| PDB=1ctl | SCENE= }}
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==STRUCTURE OF THE CARBOXY-TERMINAL LIM DOMAIN FROM THE CYSTEINE RICH PROTEIN CRP==
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<StructureSection load='1ctl' size='340' side='right'caption='[[1ctl]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ctl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CTL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CTL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ctl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ctl OCA], [https://pdbe.org/1ctl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ctl RCSB], [https://www.ebi.ac.uk/pdbsum/1ctl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ctl ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CSRP1_CHICK CSRP1_CHICK] Heat stable protein, that interacts with zyxin. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ct/1ctl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ctl ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The three dimensional solution structure of the carboxy terminal LIM domain of the avian Cysteine Rich Protein (CRP) has been determined by nuclear magnetic resonance spectroscopy. The domain contains two zinc atoms bound independently in CCHC (C = Cys, H = His) and CCCC modules. Both modules contain two orthogonally-arranged antiparallel beta-sheets, and the CCCC module contains an alpha-helix at its C terminus. The modules pack due to hydrophobic interactions forming a novel global fold. The structure of the C-terminal CCCC module is essentially identical to that observed for the DNA-interactive CCCC modules of the GATA-1 and steroid hormone receptor DNA binding domains, raising the possibility that the LIM motif may have a DNA binding function.
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===STRUCTURE OF THE CARBOXY-TERMINAL LIM DOMAIN FROM THE CYSTEINE RICH PROTEIN CRP===
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Structure of the carboxy-terminal LIM domain from the cysteine rich protein CRP.,Perez-Alvarado GC, Miles C, Michelsen JW, Louis HA, Winge DR, Beckerle MC, Summers MF Nat Struct Biol. 1994 Jun;1(6):388-98. PMID:7664053<ref>PMID:7664053</ref>
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{{ABSTRACT_PUBMED_7664053}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1ctl" style="background-color:#fffaf0;"></div>
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[[1ctl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CTL OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:007664053</ref><references group="xtra"/>
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</StructureSection>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Beckerle, M C.]]
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[[Category: Large Structures]]
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[[Category: Louis, H A.]]
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[[Category: Beckerle MC]]
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[[Category: Michelsen, J W.]]
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[[Category: Louis HA]]
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[[Category: Miles, C.]]
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[[Category: Michelsen JW]]
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[[Category: Perez-Alvarado, G C.]]
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[[Category: Miles C]]
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[[Category: Summers, M F.]]
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[[Category: Perez-Alvarado GC]]
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[[Category: Winge, D R.]]
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[[Category: Summers MF]]
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[[Category: Lim domain containing protein]]
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[[Category: Winge DR]]
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[[Category: Metal-binding protein]]
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Current revision

STRUCTURE OF THE CARBOXY-TERMINAL LIM DOMAIN FROM THE CYSTEINE RICH PROTEIN CRP

PDB ID 1ctl

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