1d5s

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[[Image:1d5s.png|left|200px]]
 
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{{STRUCTURE_1d5s| PDB=1d5s | SCENE= }}
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==CRYSTAL STRUCTURE OF CLEAVED ANTITRYPSIN POLYMER==
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<StructureSection load='1d5s' size='340' side='right'caption='[[1d5s]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF CLEAVED ANTITRYPSIN POLYMER===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1d5s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D5S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D5S FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10716194}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d5s OCA], [https://pdbe.org/1d5s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d5s RCSB], [https://www.ebi.ac.uk/pdbsum/1d5s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d5s ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1d5s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D5S OCA].
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== Disease ==
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[https://www.uniprot.org/uniprot/A1AT_HUMAN A1AT_HUMAN] Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD) [MIM:[https://omim.org/entry/613490 613490]. A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age.<ref>PMID:1905728</ref> <ref>PMID:2390072</ref> <ref>PMID:2227940</ref>
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==Reference==
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== Function ==
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<ref group="xtra">PMID:010716194</ref><references group="xtra"/>
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[https://www.uniprot.org/uniprot/A1AT_HUMAN A1AT_HUMAN] Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.[:]<ref>PMID:1906855</ref> <ref>PMID:1406456</ref> Short peptide from AAT: reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).[:]<ref>PMID:1906855</ref> <ref>PMID:1406456</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d5/1d5s_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1d5s ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bonneic, B F.Le.]]
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[[Category: Large Structures]]
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[[Category: Bottomley, S P.]]
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[[Category: Bottomley SP]]
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[[Category: Dai, W.]]
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[[Category: Dai W]]
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[[Category: Dunstone, M A.]]
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[[Category: Dunstone MA]]
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[[Category: Feil, S C.]]
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[[Category: Feil SC]]
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[[Category: Parker, M W.]]
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[[Category: Le Bonneic BF]]
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[[Category: Pike, R N.]]
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[[Category: Parker MW]]
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[[Category: Rossjohn, J.]]
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[[Category: Pike RN]]
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[[Category: Whisstock, J C.]]
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[[Category: Rossjohn J]]
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[[Category: A beta sheet polymerisation]]
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[[Category: Whisstock JC]]
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[[Category: Hydrolase inhibitor]]
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[[Category: Rcl cleavage]]
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[[Category: Serpin fold]]
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Current revision

CRYSTAL STRUCTURE OF CLEAVED ANTITRYPSIN POLYMER

PDB ID 1d5s

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